Reactome | WIP binds WASP,N-WASP, activating them

WIP binds WASP,N-WASP, activating them

Stable Identifier

R-HSA-2197691

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
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    - Leishmania infection (Homo sapiens)
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        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        WIP binds WASP,N-WASP, activating them (Homo sapiens)

General

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WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11340081	Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway Rohatgi, R, Nollau, P, Ho, HY, Kirschner, MW, Mayer, BJ	J Biol Chem	2001
10878810	A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization Moreau, V, Frischknecht, F, Reckmann, I, Vincentelli, R, Rabut, G, Stewart, D, Way, M	Nat Cell Biol	2000
11829459	WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation Kato, M, Miki, H, Kurita, S, Endo, T, Nakagawa, H, Miyamoto, S, Takenawa, T	Biochem Biophys Res Commun	2002
12213210	The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor Aspenström, P	Exp Cell Res	2002
11553796	CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family Ho, HY, Rohatgi, R, Ma, L, Kirschner, MW	Proc Natl Acad Sci U S A	2001
11157975	A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42 Fukuoka, M, Suetsugu, S, Miki, H, Fukami, K, Endo, T, Takenawa, T	J Cell Biol	2001
10781580	GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex Carlier, MF, Nioche, P, Broutin-L'Hermite, I, Boujemaa, R, Le Clainche, C, Egile, C, Garbay, C, Ducruix, A, Sansonetti, P, Pantaloni, D	J Biol Chem	2000