Activation of WASP/N-WASP by WIP family and SH3 domain proteins

Stable Identifier
R-HSA-2197691
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WASP interacting proteins (WIP) family includes WIPF1 (WIP), WIPF2 (WIRE,WICH) and WIPF3 (CR16, corticosteroids and regional expression-16). WIPs share a specific proline rich sequence that interacts with the WH1 domain of WASP and N-WASP (WASL). WIPs form heterocomplexes with WASPs and may contribute to the WASP protein stability (Aspenstrom 2002, Kato et al. 2002, Ho et al. 2001, Moreau et al. 2000).
SH3 domain containing adaptor proteins like GRB2 (Carlier et al. 2000), NCK (Rohatgi et al. 2001) and WISH (DIP/SPIN90) (Fukuoka et al. 2001) bind to the proline rich domain in WASPs and activate the ARP2/3 complex. By binding simultaneously to N-WASP and the ARP2/3 complex, GRB2 works synergistically with CDC42 in the activation of ARP2/3 complex-mediated actin assembly (Carlier et al. 2000).

Literature References
PubMed ID Title Journal Year
10878810 A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

Moreau, V, Frischknecht, F, Reckmann, I, Vincentelli, R, Rabut, G, Stewart, D, Way, M

Nat Cell Biol 2000
11340081 Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

Rohatgi, R, Nollau, P, Ho, HY, Kirschner, MW, Mayer, BJ

J Biol Chem 2001
11829459 WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation

Kato, M, Miki, H, Kurita, S, Endo, T, Nakagawa, H, Miyamoto, S, Takenawa, T

Biochem Biophys Res Commun 2002
12213210 The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor

Aspenström, P

Exp Cell Res 2002
11553796 CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family

Ho, HY, Rohatgi, R, Ma, L, Kirschner, MW

Proc Natl Acad Sci U S A 2001
11157975 A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

Fukuoka, M, Suetsugu, S, Miki, H, Fukami, K, Endo, T, Takenawa, T

J Cell Biol 2001
10781580 GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

Carlier, MF, Nioche, P, Broutin-L'Hermite, I, Boujemaa, R, Le Clainche, C, Egile, C, Garbay, C, Ducruix, A, Sansonetti, P, Pantaloni, D

J Biol Chem 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created