Branching and elongation of mother and daughter filaments

Stable Identifier
R-HSA-2029473
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Branching and elongation of mother and daughter filaments
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ATP bound G-actin monomers are added to the fast growing barbed ends of both mother and daughter filaments. The polymerization of these filaments drives membrane protrusion. In the process of phagocytosis, pseudopodia extend around the antibody-bound particle to form the phagocytic cup. This elongation continues until the filament reaches steady state equilibrium with free G-actin monomers (Millard et al. 2004, Le Clainche et al. 2008).
Literature References
PubMed ID Title Journal Year
18391171 Regulation of actin assembly associated with protrusion and adhesion in cell migration

Le Clainche, C, Carlier, MF

Physiol Rev 2008
15040784 Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

Sharp, SJ, Machesky, LM, Millard, TH

Biochem J 2004
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Orthologous Events
Branching and elongation of mother and daughter filaments (Bos taurus)
Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)
Branching and elongation of mother and daughter filaments (Canis familiaris)
Branching and elongation of mother and daughter filaments (Danio rerio)
Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)
Branching and elongation of mother and daughter filaments (Drosophila melanogaster)
Branching and elongation of mother and daughter filaments (Gallus gallus)
Branching and elongation of mother and daughter filaments (Mus musculus)
Branching and elongation of mother and daughter filaments (Rattus norvegicus)
Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)
Branching and elongation of mother and daughter filaments (Schizosaccharomyces pombe)
Branching and elongation of mother and daughter filaments (Sus scrofa)
Branching and elongation of mother and daughter filaments (Xenopus tropicalis)
Authored
Jupe, S  (2009-09-02)
Reviewed
Rosales, C  (2012-05-15)
Rivero Crespo, F  (2014-12-26)
Created
Garapati, P V  (2012-01-04)
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