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WASPs or WAVEs activate the ARP2/3 complex
Stable Identifier
R-HSA-442592
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
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Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).
Literature References
PubMed ID
Title
Journal
Year
11747816
Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities
Kranitz, H
,
Lempert, L
,
Zalevsky, J
,
Mullins, RD
Curr Biol
2001
11329366
WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement
Miki, H
,
Takenawa, T
J Cell Sci
2001
Participants
Input
ARP2/3 complex (ATP bound) [cytosol]
(Homo sapiens)
G-actin [cytosol]
(Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane]
(Homo sapiens)
Output
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol]
(Homo sapiens)
Participates
as an event of
FCGR3A-mediated phagocytosis (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Inferred From
WASP/N-WASP activate the Arp2/3 complex (Rattus norvegicus)
Authored
Jupe, S (2009-09-02)
Reviewed
Rosales, C (2012-05-15)
Rivero Crespo, F (2014-12-26)
Created
Jupe, S (2009-09-28)
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