WASPs or WAVEs activate the ARP2/3 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Once WASPs (WASP and N-WASP) and WAVEs (WAVE2 and probably WAVE1 and WAVE3) are activated, their VCA region becomes available for binding to the ARP2/3 complex and actin monomer (G-actin). The actin monomer binds to the V domain and ARP2/3 complex binds to the CA domain. The simultaneous binding of G-actin and the ARP2/3 complex to the VCA region contributes to the activation of the ARP2/3-complex-mediated actin polymerization. The VCA module acts as a platform on which an actin monomer binds to the ARP2/3 complex to trigger actin polymerization (Takenawa & Suetsugu 2007).

Literature References
PubMed ID Title Journal Year
11329366 WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement

Takenawa, T, Miki, H

J Cell Sci 2001
11747816 Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities

Zalevsky, J, Lempert, L, Kranitz, H, Mullins, RD

Curr Biol 2001
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