Detachment of WASP/WAVE

Stable Identifier
R-HSA-2197690
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Detachment of WASP/WAVE
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After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).

Literature References
PubMed ID Title Journal Year
12743368 ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays

Le Clainche, C, Pantaloni, D, Carlier, MF

Proc Natl Acad Sci U S A 2003
16880808 Arp2/3 ATP hydrolysis: to branch or to debranch?

Kovar, DR

Nat Cell Biol 2006
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Detachment of WASP/WAVE (Bos taurus)
Detachment of WASP/WAVE (Caenorhabditis elegans)
Detachment of WASP/WAVE (Canis familiaris)
Detachment of WASP/WAVE (Danio rerio)
Detachment of WASP/WAVE (Dictyostelium discoideum)
Detachment of WASP/WAVE (Drosophila melanogaster)
Detachment of WASP/WAVE (Gallus gallus)
Detachment of WASP/WAVE (Mus musculus)
Detachment of WASP/WAVE (Rattus norvegicus)
Detachment of WASP/WAVE (Sus scrofa)
Detachment of WASP/WAVE (Xenopus tropicalis)
Authored
Garapati, P V  (2012-01-04)
Reviewed
Rosales, C  (2012-05-15)
Rivero Crespo, F  (2014-12-26)
Created
Garapati, P V  (2012-04-14)