Detachment of WASP/WAVE

Stable Identifier
R-HSA-2197690
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).

Literature References
PubMed ID Title Journal Year
12743368 ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays

Le Clainche, C, Pantaloni, D, Carlier, MF

Proc Natl Acad Sci U S A 2003
16880808 Arp2/3 ATP hydrolysis: to branch or to debranch?

Kovar, DR

Nat Cell Biol 2006
Participants
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Orthologous Events
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