Reactome | Detachment of WASP/WAVE

Detachment of WASP/WAVE

Stable Identifier

R-HSA-2197690

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Parasite infection (Homo sapiens)
      - Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        Detachment of WASP/WAVE (Homo sapiens)

General

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After incorporation at the branch, the actin bound to VCA domain of WASP/WAVE undergoes ATP hydrolysis and this destabilizes its interaction with WASP/WAVE. This dissociates the branched junction from the membrane-bound WASP/WAVE (Kovar 2006).

Literature References

PubMed ID	Title	Journal	Year
12743368	ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays Le Clainche, C, Pantaloni, D, Carlier, MF	Proc Natl Acad Sci U S A	2003
16880808	Arp2/3 ATP hydrolysis: to branch or to debranch? Kovar, DR	Nat Cell Biol	2006