IgG binds LPG1G2 in the amastigote form of Leishmania

Stable Identifier
R-HSA-9664397
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IgG binds LPG1G2 in the amastigote form of Leishmania
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The internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind FcγRs, stimulating the uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice, binds the GIPL molecules on the amastigote stage of L. mexicana to subsequently induced the phagocytosis through FcγRs (Buxbaum 2013).

Literature References
Participants
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Output
Participates
as an event of
Event Information
Go Biological Process
opsonization (0008228)
Inferred From
Mouse IgG binds LPG1G2 in the amastigote form of Leishmania (Mus musculus)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI  (2019-10-22)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
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