IgG binds LPG1G2 in the amastigote form of Leishmania

Stable Identifier
R-HSA-9664397
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
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The internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind FcγRs, stimulating the uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice, binds the GIPL molecules on the amastigote stage of L. mexicana to subsequently induced the phagocytosis through FcγRs (Buxbaum 2013).

Participants
Participant Of
Event Information
Go Biological Process
Inferred From
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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Reviewed
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