PIP3 binds stimulating VAV

Stable Identifier
R-HSA-434637
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Vav interacts directly with PIP2 and PIP3, with a fivefold selectivity for PIP3 over PIP2. PIP3 gives a twofold stimulation of Vav1 GEF activity while PIP2 leads to 90% inhibition. Binding probably occurs through the PH domain, known to bind phosphoinositides.

Literature References
PubMed ID Title Journal Year
9438848 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

Han, J, Luby-Phelps, K, Das, B, Shu, X, Xia, Y, Mosteller, RD, Krishna, UM, Falck, JR, White, MA, Broek, D

Science 1998
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