Src phosphorylate WASP,N-WASP

Stable Identifier
Reaction [transition]
Homo sapiens
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WASP is phosphorylated on Tyr291 (Cory et al. 2002) and N-WASP (WASL) on Tyr256 (Wu et al. 2004) by Src family of tyrosine kinases and this phosphorylation may release the autoinhibitory intramolecular interactions. The phosphorylation seems to be enhanced by the activation of CDC42. WASP phosphorylation and binding of CDC42 have a synergistic effect on the activation of the ARP2/3 complex (Takenawa & Suetsugu 2007). In N-WASP, the phosphorylation may reduce its nuclear translocation and may sustain it in its functional site in the cytoplasm (Wu et al. 2004).

Literature References
PubMed ID Title Journal Year
12235133 Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

Ridley, AJ, Garg, R, Cramer, R, Cory, GO

J Biol Chem 2002
14676198 Focal adhesion kinase regulation of N-WASP subcellular localization and function

Guan, JL, Takenawa, T, Wu, X, Cooper, LA, Suetsugu, S

J Biol Chem 2004
Catalyst Activity

protein tyrosine kinase activity of Src-kinases [cytosol]

Orthologous Events
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