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IgG binds the surface of the amastigote form of Leishmania
Stable Identifier
R-HSA-9666433
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)
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The internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind Fc gamma receptors (FCGRs), stimulating their uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice binds GIPL molecules on the amastigote stage of L. mexicana to subsequently induce phagocytosis through FCGRs (Buxbaum 2013).
Literature References
PubMed ID
Title
Journal
Year
18070890
FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions
Thomas, BN
,
Buxbaum, LU
Infect. Immun.
2008
23675550
Leishmania mexicana infection induces IgG to parasite surface glycoinositol phospholipids that can induce IL-10 in mice and humans
Buxbaum, LU
PLoS Negl Trop Dis
2013
21037092
IgG1 is pathogenic in Leishmania mexicana infection
Thomas, BN
,
Chu, N
,
Patel, SR
,
Buxbaum, LU
J. Immunol.
2010
Participants
Input
IgG [extracellular region]
(Homo sapiens)
Lma amastigote surface [plasma membrane]
(Leishmania major)
Output
IgG:Lma amastigote surface [plasma membrane]
(Homo sapiens)
Participates
as an event of
FCGR3A-mediated phagocytosis (Homo sapiens)
Event Information
Go Biological Process
opsonization (0008228)
Disease
Name
Identifier
Synonyms
cutaneous leishmaniasis
DOID:9111
Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Jassal, B (2019-11-12)
Murillo, JI (2019-11-05)
Reviewed
Gregory, DJ (2020-02-04)
Created
Murillo, JI (2019-11-05)
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