IgG binds the surface of the amastigote form of Leishmania

Stable Identifier
R-HSA-9666433
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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IgG binds the surface of the amastigote form of Leishmania
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The internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind Fc gamma receptors (FCGRs), stimulating their uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice binds GIPL molecules on the amastigote stage of L. mexicana to subsequently induce phagocytosis through FCGRs (Buxbaum 2013).

Literature References
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Output
Participates
as an event of
Event Information
Go Biological Process
opsonization (0008228)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Jassal, B  (2019-11-12)
Murillo, JI  (2019-11-05)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-11-05)
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