DOCK180 exchanges GTP for GDP on RAC1:GDP

Stable Identifier
R-HSA-9666428
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
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General
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RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.

Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Lee, WL, Cosio, G, Ireton, K, Grinstein, S

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Reviewed
Created