DOCK180 exchanges GTP for GDP on RAC1:GDP

Stable Identifier
R-HSA-9666428
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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DOCK180 exchanges GTP for GDP on RAC1:GDP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RAC1 is activated from inactive GDP-bound state to active GTP-bound form by the GEF activity of DOCK180:ELMO complex.
Literature References
PubMed ID Title Journal Year
17308335 Role of CrkII in Fcgamma receptor-mediated phagocytosis

Lee, WL, Cosio, G, Ireton, K, Grinstein, S

J Biol Chem 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane]

Physical Entity
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Cross References
Mondo
Authored
Murillo, JI  (2019-11-05)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-11-05)
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