Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Stable Identifier
R-HSA-9664261
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Leishmania major
Compartment
Synonyms
Phosphorylation of SYK attached to FCGR3A by Src kinases
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Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).

Literature References
PubMed ID Title Journal Year
12417718 Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells

Zhang, J, Berenstein, E, Siraganian, RP

Mol Cell Biol 2002
9042338 Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

Furlong, MT, Mahrenholz, AM, Kim, KH, Ashendel, CL, Harrison, ML, Geahlen, RL

Biochim Biophys Acta 1997
18818202 Molecular mechanism of the Syk activation switch

Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM

J Biol Chem 2008
9050880 syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

El-Hillal, O, Kurosaki, T, Yamamura, H, Kinet, JP, Scharenberg, AM

Proc Natl Acad Sci U S A 1997
9857068 Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

Lupher ML, Jr, Rao, N, Lill, NL, Andoniou, CE, Miyake, S, Clark, EA, Druker, B, Band, H

J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Src family kinases (SFKs) [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
cutaneous leishmaniasis 9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Reviewed
Created