Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Leishmania major
Phosphorylation of SYK attached to FCGR3A by Src kinases
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Multiple sites of phosphorylation are known to exist in SYK, which both regulate its activity and also serve as docking sites for other proteins. Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997). Phosphorylation of these tyrosine residues disrupts autoinhibitory interactions and results in kinase activation even in the absence of phosphorylated ITAM tyrosines (Tsang et al. 2008). SYK is primarily phosphorylated by Src family kinases and this acts as an initiating trigger by generating few molecules of activated SYK which are then involved in major SYK autophosphorylation (Hillal et al. 1997).

Literature References
PubMed ID Title Journal Year
9042338 Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

Ashendel, CL, Furlong, MT, Geahlen, RL, Harrison, ML, Kim, KH, Mahrenholz, AM

Biochim Biophys Acta 1997
12417718 Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells

Zhang, J, Berenstein, E, Siraganian, RP

Mol Cell Biol 2002
18818202 Molecular mechanism of the Syk activation switch

Shaw, D, Papp, E, Gandhi, S, Tsang, E, Giannetti, AM, Tse, JK, Dinh, M, Wang, S, Ho, H, Bradshaw, JM

J Biol Chem 2008
9050880 syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

Yamamura, H, El-Hillal, O, Kinet, JP, Kurosaki, T, Scharenberg, AM

Proc Natl Acad Sci U S A 1997
9857068 Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

Rao, N, Miyake, S, Lupher ML, Jr, Lill, NL, Andoniou, CE, Druker, B, Band, H, Clark, EA

J Biol Chem 1998
Catalyst Activity

protein tyrosine kinase activity of Src family kinases (SFKs) [cytosol]

Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Cite Us!