Reactome | TRAF6 mediated IRF7 activation

TRAF6 mediated IRF7 activation

Stable Identifier

R-HSA-933541

Type

Pathway

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

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TRAF6 is crucial for both DDX58 (RIG-I)- and IFIH1 (MDA5)-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL6 after infection with RNA virus. Activation of NF-kB and IRF7, but not that of IRF3, was significantly impaired during RIG-like helicases (RLHs) signaling in the absence of TRAF6. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7. These results strongly suggest that the TRAF6- and TRAF3-dependent pathways are likely to bifurcate at mitochondrial antiviral-signaling protein MAVS (IPS-1), but to converge later at IRF7 in order to co-operatively induce sufficient production of type I IFNs during RLH signaling.

Literature References

PubMed ID	Title	Journal	Year
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J	PLoS One	2009