Reactome | TRAF mediated activation of IRF

TRAF mediated activation of IRF

Stable Identifier

R-GGA-1227882

Type

Pathway

Species

Gallus gallus

Related Species

Infectious bronchitis virus

ReviewStatus

5/5

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Once activated, IPS-1 recruits TRAFs (TNF receptor associated factor protein family members) to the RIG-1/MDA5 receptor complex. TRAF3 and TRAF6 act as a scaffold for the assembly of the signaling complex composed of TBK1/ IKK epsilon, leading to the activation of transcription factors IRF3 and IRF7. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7 [Konno H et al 2009, Oganesyan G et al 2006].

Transient transfection experiments in human embryonic kidney (HEK) 293 cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi and TANK [Konno H et al 2009]. TRAF3 was also shown to form complexes with IPS-1, TBK1 and IKKi [Oganesyan G et al 2006, Alff PJ et al 2008, Saha SK et al 2006]

Literature References

PubMed ID	Title	Journal	Year
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J	PLoS One	2009
16306936	Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G	Nature	2006