TRAF mediated activation of IRF

Stable Identifier
R-GGA-1227882
Type
Pathway
Species
Gallus gallus
Related Species
Infectious bronchitis virus
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Once activated, IPS-1 recruits TRAFs (TNF receptor associated factor protein family members) to the RIG-1/MDA5 receptor complex. TRAF3 and TRAF6 act as a scaffold for the assembly of the signaling complex composed of TBK1/ IKK epsilon, leading to the activation of transcription factors IRF3 and IRF7. TRAF6-induced activation of IRF is likely to be specific for IRF7, while TRAF3 is thought to activate both IRF3 and IRF7 [Konno H et al 2009, Oganesyan G et al 2006].


Transient transfection experiments in human embryonic kidney (HEK) 293 cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi and TANK [Konno H et al 2009]. TRAF3 was also shown to form complexes with IPS-1, TBK1 and IKKi [Oganesyan G et al 2006, Alff PJ et al 2008, Saha SK et al 2006]

Literature References
PubMed ID Title Journal Year
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G

Nature 2006
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J

PLoS One 2009
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