Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
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TANK acts as an adapter protein and regulates the assembly of TBK1/IKK epsilon complex with upstream signaling molecules. SIKE (for Suppressor of IKKepsilon) interacts with IKKepsilon and TBK1. SIKE is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection. Overexpression of SIKE disrupted the interactions of IKKepsilon or TBK1 with RIG-1.

Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T

PLoS One 2009
12133833 Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases

Muller, J, Bonif, M, Leonardi, A, Siebenlist, U, Chariot, A, Brown, K

J Biol Chem 2002
10581243 NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

Baltimore, D, Pomerantz, JL

EMBO J 1999
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