Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300

Stable Identifier
R-HSA-9604499
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
extracellular region
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Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
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The Interferon alpha and beta genes are transcribed and translated yielding IFNA and IFNB which are secreted. IRF7 and VAF transcription factors binds to IFN-alpha and IFN-beta promoter regions and induce the IFN-alpha and beta mRNA.

Literature References
PubMed ID Title Journal Year
9822609 Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

Marié, I, Durbin, JE, Levy, DE

EMBO J 1998
20627800 Regulation of immune cell homeostasis by type I interferons

Tough, DF, Mattei, F, Schiavoni, G

Cytokine Growth Factor Rev 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm] (Homo sapiens)
Active Unit
VAF/pIRF7:CBP/p300 [nucleoplasm]
Authored
Garapati, P V  (2010-11-18)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Shamovsky, V  (2018-04-03)
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