Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300

Stable Identifier
R-HSA-9604499
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The Interferon alpha and beta genes are transcribed and translated yielding IFNA and IFNB which are secreted. IRF7 and VAF transcription factors binds to IFN-alpha and IFN-beta promoter regions and induce the IFN-alpha and beta mRNA.
Literature References
PubMed ID Title Journal Year
9822609 Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

Marié, I, Durbin, JE, Levy, DE

EMBO J 1998
20627800 Regulation of immune cell homeostasis by type I interferons

Tough, DF, Mattei, F, Schiavoni, G

Cytokine Growth Factor Rev 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm] (Homo sapiens)
Active Unit
VAF/pIRF7:CBP/p300 [nucleoplasm]
Authored
Garapati, P V  (2010-11-18)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Shamovsky, V  (2018-04-04)
Cite Us!