Phosphorylation and release of IRF7

Stable Identifier
R-HSA-933525
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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Phosphorylation and release of IRF7
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IRF7 is activated through phosphorylation of residues Ser477 and Ser479 by TBK1/IKKi kinase complex.

Literature References
PubMed ID Title Journal Year
16914100 Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway

Paz, S, Sun, Q, Nakhaei, P, Romieu-Mourez, R, Goubau, D, Julkunen, I, Lin, R, Hiscott, J

Cell Mol Biol (Noisy-le-grand) 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane]
Physical Entity
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane]
Activity
protein serine/threonine kinase activity (0004674)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-16)