Phosphorylation and release of IRF7

Stable Identifier
R-HSA-933525
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation and release of IRF7
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IRF7 is activated through phosphorylation of residues Ser477 and Ser479 by TBK1/IKKi kinase complex.
Literature References
PubMed ID Title Journal Year
16914100 Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway

Hiscott, J, Paz, S, Lin, R, Romieu-Mourez, R, Goubau, D, Nakhaei, P, Sun, Q, Julkunen, I

Cell Mol Biol (Noisy-le-grand) 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane]

Physical Entity
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
Cite Us!