Phosphorylation and release of IRF7

Stable Identifier
R-HSA-933525
Type
Reaction
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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Phosphorylation and release of IRF7
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IRF7 is activated through phosphorylation of residues Ser477 and Ser479 by TBK1/IKKi kinase complex.

Literature References
PubMed ID Title Journal Year
16914100 Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway

Hiscott, J, Paz, S, Lin, R, Romieu-Mourez, R, Goubau, D, Nakhaei, P, Sun, Q, Julkunen, I

Cell Mol Biol (Noisy-le-grand) 2006
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane]

Physical Entity
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE:IRF7 [mitochondrial outer membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
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