Reactome | Recruitment of TRAF6/TRAF2 to MAVS

Recruitment of TRAF6/TRAF2 to MAVS

Stable Identifier

R-HSA-918230

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

Synonyms

Recruitment of TRAF6/TRAF2 to IPS-1

ReviewStatus

5/5

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Mitochondrial antiviral-signaling protein (MAVS or IPS-1) interacts with TRAF2 and TRAF6 through its consensus TRAF-interaction motif (TIM) (TRAF2 143-PVGET-147 and TRAF6 153-PGENSE-158 & 455-PEENEY-460). Although MAVS (IPS-1) can bind to both TRAF6 and TRAF2, TRAF2 binding is not required for MAVS activation of NF-kappaB.

Literature References

PubMed ID	Title	Journal	Year
16153868	VISA is an adapter protein required for virus-triggered IFN-beta signaling Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB	Mol Cell	2005
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J	PLoS One	2009