Recruitment of TRAF6/TRAF2 to IPS-1

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
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IPS-1 interacts with TRAF2 and TRAF6 through its consensus TRAF-interaction motif (TIM) (TRAF2 143-PVGET-147 and TRAF6 153-PGENSE-158 & 455-PEENEY-460). Although IPS-1 can bind to both TRAF6 and TRAF2, TRAF2 binding is not required for IPS-1 activation of NF-kB.

Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J

PLoS One 2009
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB

Mol Cell 2005
Participant Of
Orthologous Events
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