Reactome | Recruitment of TRAF6/TRAF2 to IPS-1

Recruitment of TRAF6/TRAF2 to IPS-1

Stable Identifier

R-HSA-918230

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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IPS-1 interacts with TRAF2 and TRAF6 through its consensus TRAF-interaction motif (TIM) (TRAF2 143-PVGET-147 and TRAF6 153-PGENSE-158 & 455-PEENEY-460). Although IPS-1 can bind to both TRAF6 and TRAF2, TRAF2 binding is not required for IPS-1 activation of NF-kB.

Literature References

PubMed ID	Title	Journal	Year
16153868	VISA is an adapter protein required for virus-triggered IFN-beta signaling Xu, LG, Shu, HB, Han, KJ, Wang, YY, Zhai, Z, Li, LY	Mol Cell	2005
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T	PLoS One	2009