Recruitment of TANK to TRAF6

Stable Identifier
R-HSA-933537
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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Recruitment of TANK to TRAF6
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TRAF family member-associated NF-kB activator (TANK, also known as I-TRAF) plays an important role in IFN induction through both RIG-I and Toll-like receptor-dependent pathways. TANK has been identified as a TRAF6 binding protein. Transient transfection experiments in 293T cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi, and TANK (Konno et al. 2009).

Literature References
PubMed ID Title Journal Year
17327220 Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

Guo, B, Cheng, G

J Biol Chem 2007
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J

PLoS One 2009
19668221 TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

Kawagoe, T, Takeuchi, O, Takabatake, Y, Kato, H, Isaka, Y, Tsujimura, T, Akira, S

Nat Immunol 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-16)