Recruitment of TANK to TRAF6

Stable Identifier
R-HSA-933537
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Recruitment of TANK to TRAF6
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TRAF family member-associated NF-kappaB activator (TANK, also known as I-TRAF) plays an important role in IFN induction through both RIG-I and Toll-like receptor-dependent pathways. TANK has been identified as a TRAF6 binding protein. Transient transfection experiments in 293T cells revealed that TRAF6 associates with MAVS (IPS-1), TBK1, IKBKE (IKKi), and TANK (Konno et al. 2009).
Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T

PLoS One 2009
17327220 Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

Guo, B, Cheng, G

J Biol Chem 2007
19668221 TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

Takeuchi, O, Tsujimura, T, Akira, S, Isaka, Y, Kato, H, Takabatake, Y, Kawagoe, T

Nat Immunol 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
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