Reactome | Recruitment of TANK to TRAF6

Recruitment of TANK to TRAF6

Stable Identifier

R-HSA-933537

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

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TRAF family member-associated NF-kB activator (TANK, also known as I-TRAF) plays an important role in IFN induction through both RIG-I and Toll-like receptor-dependent pathways. TANK has been identified as a TRAF6 binding protein. Transient transfection experiments in 293T cells revealed that TRAF6 associates with IPS-1, TBK1, IKKi, and TANK (Konno et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
17327220	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK Guo, B, Cheng, G	J Biol Chem	2007
19479062	TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J	PLoS One	2009
19668221	TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis Kawagoe, T, Takeuchi, O, Takabatake, Y, Kato, H, Isaka, Y, Tsujimura, T, Akira, S	Nat Immunol	2009