Translocation of p-IRF7:p-IRF7 to nucleus

Stable Identifier
R-HSA-933531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes.

Literature References
PubMed ID Title Journal Year
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

MariƩ, I, Smith, E, Prakash, A, Levy, DE

Mol Cell Biol 2000
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Orthologous Events
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