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VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
Stable Identifier
R-HSA-1028819
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes (Homo sapiens)
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IRF7 and VAF transcription factors binds to IFN-alpha and IFN-beta promoter regions and induce the IFN-alpha and beta mRNA.
Literature References
PubMed ID
Title
Journal
Year
9822609
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
MariƩ, I
,
Durbin, JE
,
Levy, DE
EMBO J
1998
Participants
Input
Type-I IFN genes [nucleoplasm]
(Homo sapiens)
VAF/pIRF7:CBP/p300 [nucleoplasm]
(Homo sapiens)
Output
VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TRAF6 mediated IRF7 activation (Homo sapiens)
Authored
Garapati, P V (2010-08-02)
Reviewed
Akira, S (2010-10-30)
Kawai, T (2010-10-30)
Created
Garapati, P V (2010-11-18)
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