Recruitment of IRF7 to TRAF6

Stable Identifier
R-HSA-933538
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF6 associates with and activates IRF7 but not IRF3.

Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J

PLoS One 2009
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Sato, S, Ishii, KJ, Coban, C, Hemmi, H, Yamamoto, M, Terai, K, Matsuda, M, Inoue, J, Uematsu, S, Takeuchi, O, Akira, S

Nat Immunol 2004
Participants
Participant Of
Authored
Reviewed
Created