Recruitment of IRF7 to TRAF6

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Locations in the PathwayBrowser
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TRAF6 associates with and activates IRF7 but not IRF3.

Literature References
PubMed ID Title Journal Year
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Konno, H, Yamamoto, T, Yamazaki, K, Gohda, J, Akiyama, T, Semba, K, Goto, H, Kato, A, Yujiri, T, Imai, T, Kawaguchi, Y, Su, B, Takeuchi, O, Akira, S, Tsunetsugu-Yokota, Y, Inoue, J

PLoS One 2009
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Sato, S, Ishii, KJ, Coban, C, Hemmi, H, Yamamoto, M, Terai, K, Matsuda, M, Inoue, J, Uematsu, S, Takeuchi, O, Akira, S

Nat Immunol 2004
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