Recruitment of IRF7 to TRAF6

Stable Identifier
R-HSA-933538
Type
Reaction
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
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TRAF6 associates with and activates IRF7 but not IRF3.

Literature References
PubMed ID Title Journal Year
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Takeuchi, O, Inoue, J, Matsuda, M, Terai, K, Ishii, KJ, Sato, S, Yamamoto, M, Akira, S, Uematsu, S, Coban, C, Hemmi, H

Nat Immunol 2004
19479062 TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA

Takeuchi, O, Kato, A, Goto, H, Tsunetsugu-Yokota, Y, Su, B, Yamazaki, K, Yamamoto, T, Inoue, J, Semba, K, Akira, S, Akiyama, T, Gohda, J, Konno, H, Kawaguchi, Y, Imai, T, Yujiri, T

PLoS One 2009
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