Dimerization of p-IRF7

Stable Identifier
R-HSA-933533
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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Dimerization of p-IRF7
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Phosphorylation stimulates the C-terminal autoinhibitory domain of IRF7 to attain a highly extended conformation triggering dimerization through extensive contacts to a second IRF7 subunit.

Literature References
PubMed ID Title Journal Year
20043992 Structural insights into interferon regulatory factor activation

Chen, W, Royer WE, Jr

Cell Signal 2010
11073981 Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain

Marié, I, Smith, E, Prakash, A, Levy, DE

Mol Cell Biol 2000
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Orthologous Events
Dimerization of p-IRF7 (Bos taurus)
Dimerization of p-IRF7 (Canis familiaris)
Dimerization of p-IRF7 (Danio rerio)
Dimerization of p-IRF7 (Gallus gallus)
Dimerization of p-IRF7 (Mus musculus)
Dimerization of p-IRF7 (Rattus norvegicus)
Dimerization of p-IRF7 (Sus scrofa)
Dimerization of p-IRF7 (Xenopus tropicalis)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-16)