Reactome | ATP6V0D1 [endosome membrane]

ATP6V0D1 [endosome membrane]

Stable Identifier

R-HSA-912592

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - ATP6AP1 binds V-ATPase (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0D [endosome membrane] (Homo sapiens)
        
        ATP6V0D1 [endosome membrane] (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0D [endosome membrane] (Homo sapiens)
        
        ATP6V0D1 [endosome membrane] (Homo sapiens)
      - Endosome acidification (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0D [endosome membrane] (Homo sapiens)
        
        ATP6V0D1 [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61421 ATPV0D1

Gene Names

ATPV0D1, ATP6V0D1, ATP6D, VPATPD

Chain

chain:1-351

Reference Genes

BioGPS Gene:9114 ATPV0D1

COSMIC (genes):ATP6V0D1 ATPV0D1

CTD Gene:9114 ATPV0D1

dbSNP Gene:9114 ATPV0D1

ENSEMBL:ENSG00000159720 ATPV0D1

HGNC:13724 ATPV0D1

KEGG:hsa:9114 ATPV0D1

Monarch:9114 ATPV0D1

NCBI Gene:9114 ATPV0D1

OMIM:607028 ATPV0D1

UCSC:P61421 ATPV0D1

Reference Transcript

RefSeq:NM_004691.4 ATPV0D1

Other Identifiers

11718195_a_at

11718196_x_at

11749317_a_at

11763422_a_at

11763423_x_at

11763523_at

11763808_x_at

16827366

212041_PM_at

212041_at

239633_at

3695695

3695697

3695698

3695700

3695701

3695702

3695703

3695704

3695705

3695706

3695708

3695709

3695712

3695714

3695716

3695717

3695718

3695719

3695720

3695723

3695724

3695725

38686_at

8002041

83499_at

9114

A_23_P54636

A_33_P3365710

GE59977

GO:0000220

GO:0005215

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005813

GO:0005815

GO:0006811

GO:0006879

GO:0007034

GO:0007035

GO:0008021

GO:0010008

GO:0016020

GO:0016241

GO:0016324

GO:0016471

GO:0030030

GO:0030665

GO:0030670

GO:0030672

GO:0031410

GO:0032991

GO:0033176

GO:0033179

GO:0033181

GO:0036295

GO:0043226

GO:0043679

GO:0044782

GO:0044877

GO:0046961

GO:0055085

GO:0060271

GO:0070062

GO:0097401

GO:0140657

GO:1902495

GO:1902600

HMNXSV003017160

HMNXSV003020067

Hs.106876.0.A1_3p_at

Hs.156912.0.A1_3p_at

ILMN_1795826

PH_hs_0005944

TC16001190.hg

TC16001933.hg

X71490_at

Participates

as an output of

Expression of ATP6VOD1 (Homo sapiens)

as a member of

ATP6V0D [endosome membrane] (Homo sapiens)

Other forms of this molecule

ATP6V0D1 [phagocytic vesicle membrane]

ATP6V0D1 [lysosomal membrane]

Inferred To

vma6 [endosome membrane] (Schizosaccharomyces pombe)

VMA6 [endosome membrane] (Saccharomyces cerevisiae)

atp6v0d1 [endosome membrane] (Danio rerio)

atp6v0d1 [endosome membrane] (Xenopus tropicalis)

vatD-2 [endosome membrane] (Dictyostelium discoideum)

Atp6v0d1 [endosome membrane] (Mus musculus)

Atp6v0d1 [endosome membrane] (Rattus norvegicus)

ATP6V0D1 [endosome membrane] (Bos taurus)

ATP6V0D1 [endosome membrane] (Canis familiaris)

ATP6V0D1 [endosome membrane] (Gallus gallus)

ATP6V0D1 [endosome membrane] (Plasmodium falciparum)

ATP6V0D1 [endosome membrane] (Sus scrofa)

VhaAC39-1 [endosome membrane] (Drosophila melanogaster)

vha-16 [endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004682.2

Guide to Pharmacology - Targets

829

OpenTargets

ENSG00000159720

ENSEMBL

ENSP00000290949, ENST00000290949, ENSG00000159720

HPA

ENSG00000159720-ATP6V0D1

GeneCards

ATP6V0D1

PRO

P61421

Pharos - Targets

P61421

GlyGen

P61421

PDB

7UNF, 6WM2, 6WM3, 7U4T, 6WLW, 6WM4

HMDB Protein

HMDBP01349

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.666	7
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.643	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O43711 TLX3			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:P51149 RAB7A	7	RAB7A [secretory granule membrane] (R-HSA-6804969) RAB7A [plasma membrane] (R-HSA-6804990) RAB7A [cytosol] (R-HSA-8870415) RAB7A [phagocytic vesicle membrane] (R-HSA-9636586) RAB7A [lysosomal membrane] (R-HSA-2213231) GGC-RAB7A [cytosol] (R-HSA-8870438) GGC-RAB7A [lysosomal membrane] (R-HSA-8877454)	0.527	2
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.527	2
UniProt:Q9Y2Q5 LAMTOR2	5	LAMTOR2 [lysosomal membrane] (R-HSA-5653583) LAMTOR2 [endosome membrane] (R-HSA-5693293) LAMTOR2 [tertiary granule membrane] (R-HSA-6800165) LAMTOR2 [plasma membrane] (R-HSA-6806286) LAMTOR2 [specific granule membrane] (R-HSA-6800168)	0.527	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.527	2
UniProt:Q16864 ATP6V1F	1	ATP6V1F [cytosol] (R-HSA-912603)	0.527	2
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.527	2
UniProt:Q9Y5K8 ATP6V1D	3	ATP6V1D [plasma membrane] (R-HSA-6800455) ATP6V1D [specific granule membrane] (R-HSA-6799710) ATP6V1D [cytosol] (R-HSA-912597)	0.527	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:Q08117-2 TLE5			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:P15976-2 GATA1			0.488	2