Reactome | ATP6V1D [cytosol]

ATP6V1D [cytosol]

Stable Identifier

R-HSA-912597

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Amino acids regulate mTORC1 (Homo sapiens)
      - RRAGA,B exchanges GDP for GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - RRAGA,B hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - RRAGC,D exchanges GTP for GDP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - RRAGC,D hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - mTORC1 binds RHEB:GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - ATP6AP1 binds V-ATPase (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)
      - Endosome acidification (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1D [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5K8 ATP6V1D

Gene Names

ATP6V1D, ATP6M, VATD

Chain

chain:1-247

Reference Genes

BioGPS Gene:51382 ATP6V1D

COSMIC (genes):ATP6V1D ATP6V1D

CTD Gene:51382 ATP6V1D

dbSNP Gene:51382 ATP6V1D

ENSEMBL:ENSG00000100554 ATP6V1D

HGNC:13527 ATP6V1D

KEGG:hsa:51382 ATP6V1D

Monarch:51382 ATP6V1D

NCBI Gene:51382 ATP6V1D

OMIM:609398 ATP6V1D

UCSC:Q9Y5K8 ATP6V1D

Reference Transcript

RefSeq:NM_015994.4 ATP6V1D

Other Identifiers

11720627_a_at

11720628_s_at

11745330_a_at

16793973

208898_PM_at

208898_at

208899_PM_x_at

208899_x_at

214923_PM_at

214923_at

235864_PM_at

235864_at

33854_at

3569201

3569206

3569216

3569217

3569218

3569219

3569220

3569221

3569222

3569223

3569224

3569226

3569227

3569228

3569230

3569231

3569232

3569233

3569234

3569235

3569236

3569237

3569238

3569239

3569240

51382

7979698

86446_at

A_23_P140115

A_33_P3387463

GE62160

GO:0000139

GO:0000221

GO:0005215

GO:0005515

GO:0005654

GO:0005737

GO:0005765

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005929

GO:0006811

GO:0007035

GO:0007042

GO:0010008

GO:0016020

GO:0016241

GO:0030030

GO:0030665

GO:0031410

GO:0033176

GO:0035579

GO:0042995

GO:0043226

GO:0044782

GO:0046961

GO:0048388

GO:0051452

GO:0055085

GO:0060271

GO:0061512

GO:0061795

GO:0070062

GO:0097401

GO:0098850

GO:0140657

GO:1902600

HMNXSV003024508

Hs.199726.0.A1_3p_at

Hs.306415.0.S1_3p_at

ILMN_1797310

PH_hs_0014081

TC14001236.hg

TC14001237.hg

g11999089_3p_at

g5138992_3p_s_at

Participates

as a component of

ATP6V1 [cytosol] (Homo sapiens)

Other forms of this molecule

ATP6V1D [plasma membrane]

ATP6V1D [specific granule membrane]

Inferred To

vma8 [cytosol] (Schizosaccharomyces pombe)

ATP6V1D [cytosol] (Bos taurus)

ATP6V1D [cytosol] (Canis familiaris)

ATP6V1D [cytosol] (Gallus gallus)

ATP6V1D [cytosol] (Plasmodium falciparum)

ATP6V1D [cytosol] (Sus scrofa)

Atp6v1d [cytosol] (Mus musculus)

Atp6v1d [cytosol] (Rattus norvegicus)

vha-14 [cytosol] (Caenorhabditis elegans)

Vha36-1 [cytosol] (Drosophila melanogaster)

Ghost homologue of ATP6V1D [cytosol] (Xenopus tropicalis)

atp6v1d [cytosol] (Danio rerio)

atp6v1d [cytosol] (Dictyostelium discoideum)

VMA8 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_057078.1

Guide to Pharmacology - Targets

815

ENSEMBL

ENST00000216442, ENSP00000451167, ENSP00000216442, ENST00000554087, ENSG00000100554

OpenTargets

ENSG00000100554

GeneCards

ATP6V1D

HPA

ENSG00000100554-ATP6V1D

PRO

Q9Y5K8

Pharos - Targets

Q9Y5K8

HMDB Protein

HMDBP04023

PDB

6WM3, 6WM2, 6WLZ, 7U4T, 6WM4, 7UNF

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.643	6
UniProt:Q9UI12 ATP6V1H	2	ATP6V1H [cytosol] (R-HSA-167578) ATP6V1H [plasma membrane] (R-HSA-167602)	0.643	4
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.527	3
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2

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