Reactome | ATP6V0A2 [endosome membrane]

ATP6V0A2 [endosome membrane]

Stable Identifier

R-HSA-912595

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - ATP6AP1 binds V-ATPase (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A2 [endosome membrane] (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A2 [endosome membrane] (Homo sapiens)
      - Endosome acidification (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V0 [endosome membrane] (Homo sapiens)
        
        ATP6V0A [endosome membrane] (Homo sapiens)
        
        ATP6V0A2 [endosome membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y487 ATP6V0A2

Gene Names

ATP6V0A2

Chain

chain:1-856

Reference Genes

BioGPS Gene:23545 ATP6V0A2

COSMIC (genes):ATP6V0A2 ATP6V0A2

CTD Gene:23545 ATP6V0A2

dbSNP Gene:23545 ATP6V0A2

ENSEMBL:ENSG00000185344 ATP6V0A2

ENSEMBL_homo_sapiens_GENE:ENSG00000185344.15 ATP6V0A2

HGNC:18481 ATP6V0A2

KEGG Gene (Homo sapiens):23545 ATP6V0A2

Monarch:23545 ATP6V0A2

NCBI Gene:23545 ATP6V0A2

OMIM:611716 ATP6V0A2

UCSC:Q9Y487 ATP6V0A2

Reference Transcript

RefSeq:NM_012463.3 ATP6V0A2

Other Identifiers

11728401_at

11728402_a_at

11746933_a_at

16758697

205704_PM_s_at

205704_s_at

229572_PM_at

229572_at

235255_PM_at

235255_at

23545

3436022

3436023

3436026

3436027

3436031

3436033

3436035

3436036

3436037

3436038

3436045

3436046

3436047

3436048

3436049

3436050

3436051

3436052

3436054

3436056

3436058

3436062

3436063

3436064

3436065

3436069

3436071

3436073

3436074

37801_at

43083_at

50069_at

7959657

A_23_P87513

GE54820

GO:0000139

GO:0000220

GO:0001669

GO:0002376

GO:0005215

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005794

GO:0005886

GO:0005925

GO:0006811

GO:0006879

GO:0006914

GO:0006955

GO:0007035

GO:0010008

GO:0016020

GO:0016241

GO:0016471

GO:0030670

GO:0031410

GO:0033176

GO:0033179

GO:0036295

GO:0043226

GO:0043229

GO:0043231

GO:0046961

GO:0048471

GO:0051117

GO:0055065

GO:0055085

GO:0061795

GO:0140657

GO:1902495

GO:1902600

HMNXSV003021021

Hs.183161.0.A1_3p_at

Hs.25786.0.A1_3p_at

ILMN_1700380

PH_hs_0002269

PH_hs_0022997

TC12000993.hg

g6912717_3p_at

Participates

as a member of

ATP6V0A [endosome membrane] (Homo sapiens)

Other forms of this molecule

ATP6V0A2 [phagocytic vesicle membrane]

Inferred To

ATP6V0A2 [endosome membrane] (Bos taurus)

ATP6V0A2 [endosome membrane] (Canis familiaris)

ATP6V0A2 [endosome membrane] (Gallus gallus)

ATP6V0A2 [endosome membrane] (Plasmodium falciparum)

ATP6V0A2 [endosome membrane] (Sus scrofa)

unc-32 [endosome membrane] (Caenorhabditis elegans)

Vha100-3 [endosome membrane] (Drosophila melanogaster)

Vha100-2 [endosome membrane] (Drosophila melanogaster)

vatM [endosome membrane] (Dictyostelium discoideum)

Vha100-1 [endosome membrane] (Drosophila melanogaster)

Vha100-5 [endosome membrane] (Drosophila melanogaster)

STV1 [endosome membrane] (Saccharomyces cerevisiae)

Homologues of ATP6V0A2 [endosome membrane] (Caenorhabditis elegans)

Homologues of ATP6V0A2 [endosome membrane] (Drosophila melanogaster)

Homologues of ATP6V0A2 [endosome membrane] (Saccharomyces cerevisiae)

Atp6v0a2 [endosome membrane] (Mus musculus)

atp6v0a2 [endosome membrane] (Xenopus tropicalis)

vha-7 [endosome membrane] (Caenorhabditis elegans)

vph1 [endosome membrane] (Schizosaccharomyces pombe)

Vha100-4 [endosome membrane] (Drosophila melanogaster)

vha-5 [endosome membrane] (Caenorhabditis elegans)

VPH1 [endosome membrane] (Saccharomyces cerevisiae)

vha-6 [endosome membrane] (Caenorhabditis elegans)

atp6v0a2b [endosome membrane] (Danio rerio)

Cross References

RefSeq

NP_036595.2

Guide to Pharmacology - Targets

824

OpenTargets

ENSG00000185344

HPA

ENSG00000185344-ATP6V0A2

GeneCards

Q9Y487

Ensembl

ENSP00000332247, ENST00000330342, ENSG00000185344

PRO

Q9Y487

Pharos - Targets

Q9Y487

Orphanet

17303

HMDB Protein

HMDBP03006

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.643	4
UniProt:O15342 ATP6V0E1	3	ATP6V0E1 [endosome membrane] (R-HSA-912582) ATP6V0E1 [phagocytic vesicle membrane] (R-HSA-1222533) ATP6V0E1 [lysosomal membrane] (R-HSA-9640180)	0.527	2
UniProt:Q86XL3 ANKLE2	2	ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000) Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946)	0.527	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.527	3
UniProt:P01730 CD4	4	CD4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869082) CD4 [early endosome] (R-HSA-182147) CD4 [endoplasmic reticulum membrane] (R-HSA-180575) CD4 [plasma membrane] (R-HSA-167542)	0.527	2
UniProt:Q8WZA1 POMGNT1	6	POMGNT1 P493R [Golgi membrane] (R-HSA-5617048) POMGNT1 W475* [Golgi membrane] (R-HSA-5617097) POMGNT1 R63* [Golgi membrane] (R-HSA-5617033) POMGNT1 R605Vfs*29 [Golgi membrane] (R-HSA-5617081) POMGNT1 S550N [Golgi membrane] (R-HSA-5617094) POMGNT1 [Golgi membrane] (R-HSA-5617040)	0.527	2
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.527	2
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2

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