Reactome | SPINT2 [extracellular region]

SPINT2 [extracellular region]

Stable Identifier

R-HSA-6800233

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Kunitz-type protease inhibitor 2, SPIT2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43291 SPINT2

Gene Names

SPINT2, HAI2, KOP

Chain

signal peptide:1-27, chain:28-252

Reference Genes

BioGPS Gene:10653 SPINT2

COSMIC (genes):SPINT2 SPINT2

CTD Gene:10653 SPINT2

dbSNP Gene:10653 SPINT2

ENSEMBL:ENSG00000167642 SPINT2

HGNC:11247 SPINT2

KEGG:hsa:10653 SPINT2

Monarch:10653 SPINT2

NCBI Gene:10653 SPINT2

OMIM:605124 SPINT2

UCSC:O43291 SPINT2

Reference Transcript

Other Identifiers

10653

11742851_x_at

11745496_a_at

16861630

210715_PM_s_at

210715_s_at

34348_at

3832257

3832258

3832259

3832260

3832262

3832264

3832265

3832266

3832267

3832268

3832269

3832270

3832271

3832272

3832273

3832274

3832275

3832276

3832277

8028311

A_14_P131709

A_23_P27795

GE82588

GO:0001843

GO:0004866

GO:0004867

GO:0005576

GO:0005737

GO:0005886

GO:0007163

GO:0016020

GO:0022408

GO:0030198

GO:0060672

GO:0071711

GO:0071773

GO:0098772

GO:2000146

GO:2000178

HMNXSV003042887

ILMN_1800739

PH_hs_0002675

TC19000522.hg

U78095_at

g2598967_3p_a_at

Participates

as a member of

SPINT1,2 [extracellular region] (Homo sapiens)

Inferred To

SPINT2 [extracellular region] (Bos taurus)

SPINT2 [extracellular region] (Canis familiaris)

SPINT2 [extracellular region] (Sus scrofa)

spint2 [extracellular region] (Xenopus tropicalis)

Spint2 [extracellular region] (Mus musculus)

Spint2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001159575.1, NP_066925.1

ENSEMBL

ENSG00000167642, ENST00000454580, ENSP00000301244, ENSP00000389788, ENST00000301244

OpenTargets

ENSG00000167642

GeneCards

SPINT2

HPA

ENSG00000167642-SPINT2

PRO

O43291

Pharos - Targets

O43291

GlyGen

O43291

Orphanet

SPINT2

PDB

4U32

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99640 PKMYT1	3	PKMYT1 [nucleoplasm] (R-HSA-74386) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [cytosol] (R-HSA-157457)	0.527	2
UniProt:P07099 EPHX1	1	EPHX1 [endoplasmic reticulum membrane] (R-HSA-5694132)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:Q6NUM9 RETSAT	1	RETSAT [endoplasmic reticulum membrane] (R-HSA-2980901)	0.527	3
UniProt:Q9ULF5 SLC39A10	1	SLC39A10 [plasma membrane] (R-HSA-442377)	0.527	2
UniProt:Q16850 CYP51A1	1	CYP51A1 [endoplasmic reticulum membrane] (R-HSA-194721)	0.527	3
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.527	2
UniProt:Q15058 KIF14	1	KIF14 [cytosol] (R-HSA-1629804)	0.527	2

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