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GPR17 [plasma membrane]
Stable Identifier
R-HSA-416429
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Uracil nucleotide/cysteinyl leukotriene receptor, GPR17_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Leukotriene receptors (Homo sapiens)
UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
Nucleotide-like (purinergic) receptors (Homo sapiens)
P2Y receptors (Homo sapiens)
The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13304 GPR17
Gene Names
GPR17
Chain
chain:1-367
Reference Genes
BioGPS Gene:2840 GPR17
COSMIC (genes):GPR17 GPR17
CTD Gene:2840 GPR17
dbSNP Gene:2840 GPR17
ENSEMBL:ENSG00000144230 GPR17
ENSEMBL_homo_sapiens_GENE:ENSG00000144230.17 GPR17
HGNC:4471 GPR17
KEGG Gene (Homo sapiens):2840 GPR17
Monarch:2840 GPR17
NCBI Gene:2840 GPR17
OMIM:603071 GPR17
UCSC:Q13304 GPR17
Reference Transcript
RefSeq:NM_001161417.1 GPR17
RefSeq:XM_017003833.1 GPR17
RefSeq:NM_001161416.1 GPR17
RefSeq:NM_001161415.1 GPR17
RefSeq:NM_005291.2 GPR17
Other Identifiers
11738209_a_at
11738210_x_at
11744725_a_at
16885411
206190_PM_at
206190_at
215225_PM_s_at
215225_s_at
2504744
2504746
2504747
2504749
2504750
2504751
2504752
2504753
2504754
2504755
2504756
2504757
2840
39972_at
8045075
A_14_P109423
A_23_P16963
A_33_P3236846
GE60447
GO:0002376
GO:0002862
GO:0004930
GO:0004950
GO:0005515
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0007200
GO:0016020
GO:0023052
GO:0030154
GO:0033612
GO:0035025
GO:0048709
GO:0048856
GO:0060089
GO:0070098
HMNXSV003014763
Hs.46453.1.S1_3p_a_at
ILMN_1668779
PH_hs_0003289
TC02000787.hg
U33447_at
g4885300_3p_at
Participates
as an input of
UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)
The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
GPR17:UDP [plasma membrane] (Homo sapiens)
GPR17:Cysteinyl leukotrienes [plasma membrane] (Homo sapiens)
Inferred To
Gpr17 [plasma membrane]
(Mus musculus)
Gpr17 [plasma membrane]
(Rattus norvegicus)
GPR17 [plasma membrane]
(Bos taurus)
GPR17 [plasma membrane]
(Canis familiaris)
GPR17 [plasma membrane]
(Sus scrofa)
gnrr-4 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001154887.1
,
XP_016859322.1
,
NP_001154889.1
,
NP_005282.1
,
NP_001154888.1
ZINC - World Drugs
GPR17_HUMAN
Guide to Pharmacology - Targets
88
OpenTargets
ENSG00000144230
ZINC - FDA approved
GPR17_HUMAN
ZINC - Substances
GPR17_HUMAN
ZINC target
Q13304
ZINC - Biogenic
GPR17_HUMAN
PRO
Q13304
PDB
7Y89
ZINC - Investigational
GPR17_HUMAN
ZINC - Metabolites
GPR17_HUMAN
HPA
ENSG00000144230-GPR17
GeneCards
Q13304
Ensembl
ENSG00000144230
,
ENSP00000272644
,
ENST00000272644
,
ENST00000393018
,
ENST00000544369
,
ENSP00000376741
,
ENST00000486700
,
ENSP00000508383
,
ENSP00000442982
Pharos - Targets
Q13304
ZINC - Predictions - Purchasable
GPR17_HUMAN
HMDB Protein
HMDBP10776
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