Reactome | pro-HGF [extracellular region]

pro-HGF [extracellular region]

Stable Identifier

R-HSA-6800218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

HGF(32-728), Hepatocyte growth factor alpha chain, Scatter factor, SF, Hepatopoeitin A

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14210 HGF

Gene Names

HGF, HPTA

Chain

signal peptide:1-31, chain:32-494, chain:495-728

Reference Genes

BioGPS Gene:3082 HGF

COSMIC (genes):HGF HGF

CTD Gene:3082 HGF

dbSNP Gene:3082 HGF

ENSEMBL:ENSG00000019991 HGF

HGNC:4893 HGF

KEGG:hsa:3082 HGF

Monarch:3082 HGF

NCBI Gene:3082 HGF

OMIM:142409 HGF

UCSC:P14210 HGF

Reference Transcript

Participates

as an input of

Other forms of this molecule

HGF(32-494) [extracellular region]

HGF(495-728) [extracellular region]

HGF(495-728) [platelet alpha granule lumen]

HGF(32-494) [platelet alpha granule lumen]

Inferred To

hgfa [extracellular region] (Danio rerio)

Hgf [extracellular region] (Mus musculus)

Hgf [extracellular region] (Rattus norvegicus)

pro-HGF [extracellular region] (Caenorhabditis elegans)

HGF [extracellular region] (Bos taurus)

HGF [extracellular region] (Canis familiaris)

HGF [extracellular region] (Gallus gallus)

HGF [extracellular region] (Sus scrofa)

hgf [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001010934.1, NP_001010933.1, NP_001010932.1, XP_016867587.1, XP_016867586.1, XP_011514417.1, XP_006716019.1, XP_047276249.1, NP_001010931.1, NP_000592.3

OpenTargets

ENSG00000019991

ENSEMBL

ENSP00000413829, ENSP00000408270, ENST00000444829, ENST00000222390, ENSP00000222390, ENST00000453411, ENST00000457544, ENSG00000019991, ENST00000423064, ENSP00000389854, ENSP00000391238

ZINC - Substances

HGF_HUMAN

ZINC target

P14210

PRO

P14210

GlyGen

P14210

PDB

1GP9, 3MKP, 1SI5, 4O3U, 4O3T, 1GMO, 4K3J, 1GMN, 7MO8, 5COE, 1SHY, 4D3C, 5CT3, 5CSQ, 5CT2, 2QJ2, 5CP9, 1NK1, 3HMT, 5CS9, 3HN4, 7MO9, 3HMS, 7MOA, 1BHT, 5CT1, 7MO7, 7MOB, 3SP8, 5CS1, 5CS5, 5CS3, 7OCM, 7OCL, 2HGF

HPA

ENSG00000019991-HGF

GeneCards

HGF

Pharos - Targets

P14210

Orphanet

HGF

ZINC - Predictions - Purchasable

HGF_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014)	0.851	7
UniProt:P14210 HGF	5	HGF(32-494) [extracellular region] (R-HSA-56497) HGF(495-728) [extracellular region] (R-HSA-141767) pro-HGF [extracellular region] (R-HSA-6800218) HGF(495-728) [platelet alpha granule lumen] (R-HSA-141764) HGF(32-494) [platelet alpha granule lumen] (R-HSA-139866)	0.623	2
UniProt:P16056	7	phospho-Met [plasma membrane] (R-MMU-6807014) phospho-Met [plasma membrane] (R-MMU-8875181) phospho-Met [plasma membrane] (R-MMU-8875180) phospho-Met [plasma membrane] (R-MMU-6807032) phospho-Met [plasma membrane] (R-MMU-8874689) Met [plasma membrane] (R-MMU-419603) phospho-Met [plasma membrane] (R-MMU-6806973)	0.558	2
UniProt:P50222 MEOX2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3

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