Reactome | HGF(495-728) [extracellular region]

HGF(495-728) [extracellular region]

Stable Identifier

R-HSA-141767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Hepatocyte growth factor beta chain, Scatter factor, SF, Hepatopoeitin A

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET Receptor Activation (Homo sapiens)
      - HGF dimer binds MET (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET dimers autophosphorylate (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MET dimer:TKIs [plasma membrane] (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET receptor dimerizes (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates PI3K/AKT signaling (Homo sapiens)
      - Activated MET binds GAB1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Activated MET binds GAB1 and GRB2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET bound PI3K generates PIP3 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates GAB1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates PTPN11 (Homo sapiens)
      - GAB1 binds PTPN11 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates RAS signaling (Homo sapiens)
      - Activated MET binds RANBP9 and SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Activated MET recruits GRB2-1:SOS1 (Homo sapiens)
        
        HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET binds RANBP10 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET binds SHC1-2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates SHC1-2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)
        
        HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates STAT3 (Homo sapiens)
      - MET phosphorylates STAT3 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - STAT3 binds activated MET receptor (Homo sapiens)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        MET phosphorylates PTK2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PTK2 autophosphorylates (Homo sapiens)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        SRC phosphorylates PTK2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        p-Y397-PTK2 binds SRC (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET activates RAP1 and RAC1 (Homo sapiens)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        DOCK7 activates RAC1 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        GAB1 recruits CRK,CRKL to MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        RAPGEF1 activates RAP1 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        RAPGEF1 binds CRK,CRKL (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET interacts with TNS proteins (Homo sapiens)
        
        MET binds TNS3 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        MET binds TNS4 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET receptor recycling (Homo sapiens)
      - GGA3 associates with activated MET receptor (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - CBL binds MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - CBL monoubiquitinates activated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Drug-mediated inhibition of MET activation (Homo sapiens)
        
        Anti-MET small tyrosine kinase inhibitors bind MET (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MET dimer:TKIs [plasma membrane] (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates CBL (Homo sapiens)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
        
        HGF:p-Y,1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - PTPRJ dephosphorylates MET (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14210 HGF

Gene Names

HGF, HPTA

Chain

signal peptide:1-31, chain:32-494, chain:495-728

Reference Genes

BioGPS Gene:3082 HGF

COSMIC (genes):HGF HGF

CTD Gene:3082 HGF

dbSNP Gene:3082 HGF

ENSEMBL:ENSG00000019991 HGF

HGNC:4893 HGF

KEGG Gene (Homo sapiens):3082 HGF

Monarch:3082 HGF

NCBI Gene:3082 HGF

OMIM:142409 HGF

UCSC:P14210 HGF

Reference Transcript

Other Identifiers

0006420110

1095_s_at

11730068_a_at

11732351_at

11732746_a_at

11732747_at

1340_s_at

17059165

209960_at

209961_s_at

210755_at

210997_3p_at

210997_at

210998_s_at

3058945

3058946

3058947

3058954

3058955

3058956

3058957

3058958

3058959

3058960

3058961

3058963

3058965

3058967

3058968

3058972

3058973

3058974

3058979

3058981

3058982

3058984

3058988

3058989

3082

8140556

A_23_P93780

A_23_P93787

A_24_P944788

A_33_P3276713

A_33_P3276718

GE62425

GO:0000165

GO:0000187

GO:0000278

GO:0000902

GO:0001837

GO:0001889

GO:0001934

GO:0002576

GO:0003674

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006259

GO:0006464

GO:0006508

GO:0006810

GO:0006914

GO:0006950

GO:0007005

GO:0007049

GO:0007165

GO:0007267

GO:0008083

GO:0008150

GO:0008219

GO:0008233

GO:0008283

GO:0009056

GO:0009058

GO:0010507

GO:0014068

GO:0016020

GO:0016192

GO:0019221

GO:0030154

GO:0030212

GO:0030335

GO:0031093

GO:0031100

GO:0031410

GO:0031643

GO:0032715

GO:0032733

GO:0033137

GO:0034641

GO:0035729

GO:0040011

GO:0042056

GO:0042802

GO:0043066

GO:0043154

GO:0043226

GO:0044281

GO:0044877

GO:0045669

GO:0045766

GO:0045944

GO:0048012

GO:0048646

GO:0048856

GO:0048870

GO:0050673

GO:0050728

GO:0050731

GO:0050877

GO:0050918

GO:0051450

GO:0051897

GO:0060326

GO:0060665

GO:0070572

GO:0090201

GO:1900744

GO:1901299

GO:1902042

GO:1902947

GO:2000573

HMNXSV003042284

HMNXSV003051024

HMNXSV003051887

Hs.809.0.S3_3p_at

ILMN_1757838

ILMN_1790149

ILMN_1801586

ILMN_1896012

M73239_s_at

PH_hs_0018966

TC07001562.hg

g1378041_3p_at

g184029_3p_a_at

g184029_3p_at

g184031_3p_a_at

Participates

as a component of

as an input of

IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)

Other forms of this molecule

HGF(32-494) [platelet alpha granule lumen]

HGF(495-728) [platelet alpha granule lumen]

pro-HGF [extracellular region]

HGF(32-494) [extracellular region]

Inferred To

Ghost homologue of HGF(495-728) [extracellular region] (Caenorhabditis elegans)

hgfa [extracellular region] (Danio rerio)

Hgf [extracellular region] (Mus musculus)

Hgf [extracellular region] (Rattus norvegicus)

HGF [extracellular region] (Canis familiaris)

HGF [extracellular region] (Gallus gallus)

HGF(495-728) [extracellular region] (Sus scrofa)

HGF(495-728) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

XP_016867586.1, NP_001010932.1, XP_011514417.1, NP_001010933.1, NP_001010931.1, XP_016867587.1, XP_006716019.1, NP_001010934.1, NP_000592.3

OpenTargets

ENSG00000019991

ZINC - Substances

HGF_HUMAN

ZINC target

P14210

PRO

P14210

GlyGen

P14210

PDB

5CS3, 5CT2, 1BHT, 2QJ2, 5CS5, 4O3T, 1SI5, 1SHY, 5CT3, 1GP9, 5CSQ, 5CS1, 4K3J, 5CT1, 3SP8, 5COE, 1GMN, 3HMT, 3HMS, 1NK1, 3MKP, 4O3U, 5CS9, 3HN4, 5CP9, 2HGF, 4D3C, 1GMO

HPA

ENSG00000019991-HGF

GeneCards

P14210

Ensembl

ENSP00000391238, ENST00000453411, ENST00000222390, ENSP00000389854, ENSP00000408270, ENSP00000413829, ENSP00000222390, ENST00000444829, ENST00000457544, ENST00000423064, ENSG00000019991

Pharos - Targets

P14210

Orphanet

18471

ZINC - Predictions - Purchasable

HGF_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180)	0.851	7
UniProt:P14210 HGF	5	HGF(32-494) [platelet alpha granule lumen] (R-HSA-139866) pro-HGF [extracellular region] (R-HSA-6800218) HGF(495-728) [extracellular region] (R-HSA-141767) HGF(495-728) [platelet alpha granule lumen] (R-HSA-141764) HGF(32-494) [extracellular region] (R-HSA-56497)	0.623	2
UniProt:P16056	7	phospho-Met [plasma membrane] (R-MMU-8875181) Met [plasma membrane] (R-MMU-419603) phospho-Met [plasma membrane] (R-MMU-6807014) phospho-Met [plasma membrane] (R-MMU-8875180) phospho-Met [plasma membrane] (R-MMU-8874689) phospho-Met [plasma membrane] (R-MMU-6806973) phospho-Met [plasma membrane] (R-MMU-6807032)	0.558	2
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P50222 MEOX2			0.556	3

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