Reactome | HGF(495-728) [extracellular region]

HGF(495-728) [extracellular region]

Stable Identifier

R-HSA-141767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Hepatocyte growth factor beta chain, Scatter factor, SF, Hepatopoeitin A

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-7 signaling (Homo sapiens)
      - IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF(495-728):IL7 [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET Receptor Activation (Homo sapiens)
      - HGF dimer binds MET (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET dimers autophosphorylate (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET receptor dimerizes (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates PI3K/AKT signaling (Homo sapiens)
      - Activated MET binds GAB1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Activated MET binds GAB1 and GRB2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET bound PI3K generates PIP3 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates GAB1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates PTPN11 (Homo sapiens)
      - GAB1 binds PTPN11 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates RAS signaling (Homo sapiens)
      - Activated MET binds RANBP9 and SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - Activated MET recruits GRB2-1:SOS1 (Homo sapiens)
        
        HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET binds RANBP10 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET binds SHC1-2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates SHC1-2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MUC20 binds MET and inhibits GRB2 binding (Homo sapiens)
        
        HGF:p-4Y MET dimer:MUC20 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET activates STAT3 (Homo sapiens)
      - MET phosphorylates STAT3 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - STAT3 binds activated MET receptor (Homo sapiens)
        
        HGF:p-4Y-MET dimer:STAT3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        MET phosphorylates PTK2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PTK2 autophosphorylates (Homo sapiens)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        SRC phosphorylates PTK2 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        p-Y397-PTK2 binds SRC (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET activates RAP1 and RAC1 (Homo sapiens)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        DOCK7 activates RAC1 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        GAB1 recruits CRK,CRKL to MET (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        RAPGEF1 activates RAP1 (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        RAPGEF1 binds CRK,CRKL (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET interacts with TNS proteins (Homo sapiens)
        
        MET binds TNS3 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        MET binds TNS4 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - MET receptor recycling (Homo sapiens)
      - GGA3 associates with activated MET receptor (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - CBL binds MET (Homo sapiens)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - CBL monoubiquitinates activated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:MonoUb-K,p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - MET phosphorylates CBL (Homo sapiens)
        
        HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane] (Homo sapiens)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer:p-Y-CBL [plasma membrane] (Homo sapiens)
        
        HGF:p-Y1003,4Y-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1003,4Y-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
        
        HGF:p-Y,1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
      - PTPRJ dephosphorylates MET (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)
        
        HGF:p-Y1234,Y1235,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1234,Y1235,Y1356-MET [plasma membrane] (Homo sapiens)
        
        HGF dimer [extracellular region] (Homo sapiens)
        
        HGF(495-728) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14210 HGF

Gene Names

HGF, HPTA

Chain

signal peptide:1-31, chain:32-494, chain:495-728

Reference Genes

BioGPS Gene:3082 HGF

COSMIC (genes):HGF HGF

CTD Gene:3082 HGF

dbSNP Gene:3082 HGF

ENSEMBL:ENSG00000019991 HGF

HGNC:4893 HGF

KEGG Gene (Homo sapiens):3082 HGF

Monarch:3082 HGF

NCBI Gene:3082 HGF

OMIM:142409 HGF

UCSC:P14210 HGF

Reference Transcript

Other Identifiers

0006420110

10333

1095_s_at

11730068_a_at

11732351_at

11732746_a_at

11732747_at

1340_s_at

17059165

1BHT

1GMN

1GMO

1GP9

1NK1

1SHY

1SI5

209960_at

209961_s_at

210755_at

210997_3p_at

210997_at

210998_s_at

2HGF

2QJ2

3058945

3058946

3058947

3058954

3058955

3058956

3058957

3058958

3058959

3058960

3058961

3058963

3058965

3058967

3058968

3058972

3058973

3058974

3058979

3058981

3058982

3058984

3058988

3058989

3082

3HMS

3HMT

3HN4

3MKP

3SP8

40360

44088

4D3C

4K3J

4O3T

4O3U

5COE

5CP9

5CS1

5CS3

5CS5

5CS9

5CSQ

5CT1

5CT2

5CT3

8140556

A0A2R8YEI1

A_23_P93780

A_23_P93787

A_24_P944788

A_33_P3276713

A_33_P3276718

AAA35980

AAA52648

AAA52649

AAA52650

AAA64239

AAA64297

AAC50539

AAC71655

AAG53459

AAG53460

AAH22308

AAH63485

AAI05798

AAI30285

AAI30287

AAO61091

AC004960

AY246560

BAA14348

BC022308

BC063485

BC105797

BC130284

BC130286

C9JDP4

C9JS80

C9WSJ3

C9WSJ4

CAA34387

CAA40802

CAB010333

CCDS47626

CCDS47627

CCDS47628

CCDS47629

CCDS5597

CH236949

D90334

EAL24189

ENSG00000019991

ENSP00000222390

ENSP00000389854

ENSP00000391238

ENSP00000408270

ENSP00000413829

ENST00000222390

ENST00000423064

ENST00000423064.7

ENST00000444829

ENST00000444829.7

ENST00000453411

ENST00000453411.6

ENST00000457544

ENST00000457544.7

ENST00000644543.1

EntrezGene:3082

EntrezGene:HGF

g1378041_3p_at

g184029_3p_a_at

g184029_3p_at

g184031_3p_a_at

GE62425

GO:0000165

GO:0000187

GO:0000278

GO:0000902

GO:0001837

GO:0001889

GO:0001934

GO:0002576

GO:0003674

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0006259

GO:0006464

GO:0006508

GO:0006810

GO:0006914

GO:0006950

GO:0007005

GO:0007049

GO:0007165

GO:0007267

GO:0008083

GO:0008150

GO:0008219

GO:0008233

GO:0008283

GO:0009056

GO:0009058

GO:0010507

GO:0014068

GO:0016020

GO:0016192

GO:0019221

GO:0030154

GO:0030212

GO:0030335

GO:0031093

GO:0031100

GO:0031410

GO:0031643

GO:0032715

GO:0032733

GO:0033137

GO:0034641

GO:0035729

GO:0040011

GO:0042056

GO:0042802

GO:0043066

GO:0043154

GO:0043226

GO:0044281

GO:0045669

GO:0045766

GO:0045944

GO:0046982

GO:0048012

GO:0048646

GO:0048856

GO:0048870

GO:0050673

GO:0050728

GO:0050731

GO:0050877

GO:0050918

GO:0051450

GO:0051897

GO:0060326

GO:0060665

GO:0070572

GO:0090201

GO:1900744

GO:1901299

GO:1902042

GO:1902947

GO:2000573

HGF

HGF-201

HGF-205

HGF-206

HGF-208

HGF-209

HGNC:4893

HPA040360

HPA044088

Hs.809.0.S3_3p_at

ILMN_1757838

ILMN_1790149

ILMN_1801586

ILMN_1896012

IPR000001

IPR001254

IPR001314

IPR003609

IPR009003

IPR013806

IPR018056

IPR024174

IPR027284

IPR038178

L02931

M29145

M55379

M60718

M73239

M73239_s_at

M73240

M75966

M75967

M75968

M75969

M75971

M75972

M75973

M75974

M75975

M75976

M75977

M75978

M75979

M75980

M75981

M75982

M75983

M77227

MIM:142409

MIM:608265

NM_000601

NM_001010931

NM_001010932

NM_001010933

NM_001010934

NP_000592

NP_001010931

NP_001010932

NP_001010933

NP_001010934

PF00024

PF00051

PF00089

PH_hs_0018966

PR00018

PR00722

SM00020

SM00130

SM00473

TC07001562.hg

U46010

UPI000000D92B

UPI000006F886

UPI00000720D2

UPI0000073BF9

UPI0000146316

X16323

X57574

XM_006715956

XM_011516115

XM_017012097

XM_017012098

XP_006716019

XP_011514417

XP_016867586

XP_016867587

Participant Of

hasComponent

input

IL7 binds HGF(495-728) to form PPBSF

Other forms of this molecule

HGF(32-494) [platelet alpha granule lumen]

HGF(495-728) [platelet alpha granule lumen]

pro-HGF [extracellular region]

HGF(32-494) [extracellular region]

Inferred To

Ghost homologue of HGF(495-728) [extracellular region] (Caenorhabditis elegans)

HGF(495-728) [extracellular region] (Canis familiaris)

HGF(495-728) [extracellular region] (Danio rerio)

HGF(495-728) [extracellular region] (Gallus gallus)

HGF(495-728) [extracellular region] (Mus musculus)

HGF(495-728) [extracellular region] (Rattus norvegicus)

HGF(495-728) [extracellular region] (Sus scrofa)

HGF(495-728) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001010934.1, NP_001010933.1, XP_011514417.1, XP_016867586.1, XP_006716019.1, XP_016867587.1, NP_001010932.1, NP_001010931.1, NP_000592.3

OpenTargets

ENSG00000019991

GeneCards

P14210

ZINC - Substances

HGF_HUMAN

ZINC target

P14210

PRO

P14210

Orphanet

18471

ZINC - Predictions - Purchasable

HGF_HUMAN

PDB

4O3U, 2HGF, 1SHY, 3HMS, 5CS3, 3SP8, 5CP9, 4K3J, 1BHT, 1SI5, 5CSQ, 5CT1, 3HMT, 5CS5, 1GMO, 2QJ2, 5CT2, 1GMN, 5CS9, 3HN4, 1NK1, 5COE, 4O3T, 1GP9, 4D3C, 5CT3, 5CS1, 3MKP

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.851	7
UniProt:P14210 HGF	5	HGF(495-728) [platelet alpha granule lumen] (R-HSA-141764) HGF(32-494) [platelet alpha granule lumen] (R-HSA-139866) pro-HGF [extracellular region] (R-HSA-6800218) HGF(495-728) [extracellular region] (R-HSA-141767) HGF(32-494) [extracellular region] (R-HSA-56497)	0.623	2
UniProt:P16056	7	phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-MMU-6807014) phospho-p-Y1349,Y1356-MET [plasma membrane] (R-MMU-6807032) phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-8875181) phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-MMU-8875180) phospho-p-Y1003,4Y-MET [plasma membrane] (R-MMU-8874689) MET [plasma membrane] (R-MMU-419603) phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-MMU-6806973)	0.558	2
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P50222 MEOX2			0.556	3