Reactome | cleaved GPI-GPIHBP1 [extracellular region]

cleaved GPI-GPIHBP1 [extracellular region]

Stable Identifier

R-HSA-8941062

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GPI-GPIHBP1, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, HDBP1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8IV16 GPIHBP1

Gene Names

GPIHBP1, HBP1

Chain

signal peptide:1-20, chain:21-151, propeptide:152-184

Reference Genes

BioGPS Gene:338328 GPIHBP1

COSMIC (genes):GPIHBP1 GPIHBP1

COSMIC (genes):HBP1 GPIHBP1

CTD Gene:338328 GPIHBP1

dbSNP Gene:338328 GPIHBP1

ENSEMBL:ENSG00000277494 GPIHBP1

HGNC:24945 GPIHBP1

KEGG:hsa:338328 GPIHBP1

Monarch:338328 GPIHBP1

NCBI Gene:338328 GPIHBP1

OMIM:612757 GPIHBP1

UCSC:Q8IV16 GPIHBP1

Reference Transcript

Other Identifiers

11725876_at

17073290

238062_PM_at

238062_at

3119435

3119437

3119438

3119439

3119440

3119441

3119442

3119443

338328

50768_at

8148591

A_23_P72697

GE88778

GO:0005215

GO:0005515

GO:0005576

GO:0005886

GO:0006629

GO:0006886

GO:0008289

GO:0009897

GO:0016020

GO:0016323

GO:0016324

GO:0017038

GO:0019433

GO:0034394

GO:0035473

GO:0035478

GO:0042632

GO:0045056

GO:0045723

GO:0050821

GO:0060230

GO:0070328

GO:0071503

GO:0071813

GO:0090319

GO:0090321

GO:0098552

GO:0098772

GO:0140318

GO:1902494

HMNXSV003000136

Hs.11112.0.A1_3p_at

ILMN_1726210

ILMN_1734076

ILMN_2307150

PH_hs_0019842

TC08000816.hg

TC08002148.hg

Participates

as a member of

proteins with cleaved GPI-anchors [extracellular region] (Homo sapiens)

Other forms of this molecule

GPIHBP1 [plasma membrane]

GPI-GPIHBP1 [plasma membrane]

Inferred To

LY6CLEL [extracellular region] (Gallus gallus)

Gpihbp1 [extracellular region] (Mus musculus)

Gpihbp1 [extracellular region] (Rattus norvegicus)

GPIHBP1 [extracellular region] (Bos taurus)

GPIHBP1 [extracellular region] (Canis familiaris)

GPIHBP1 [extracellular region] (Sus scrofa)

LY6E [extracellular region] (Gallus gallus)

LY6EL [extracellular region] (Gallus gallus)

BP1009 [extracellular region] (Drosophila melanogaster)

Homologues of cleaved GPI-GPIHBP1 [extracellular region] (Gallus gallus)

Modified Residues

Name

glycine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 151

Coordinate

151

Modification

6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group

PsiMod Name

glycine amide

PsiMod Definition

A protein modification that effectively converts a glycine residue to glycine amide.

Cross References

RefSeq

NP_835466.2, NP_001288701.1

OpenTargets

ENSG00000277494

ENSEMBL

ENSP00000480053, ENST00000622500, ENSG00000277494

HPA

ENSG00000277494-GPIHBP1

GeneCards

GPIHBP1

PRO

Q8IV16

Pharos - Targets

Q8IV16

Orphanet

GPIHBP1

GlyGen

Q8IV16

PDB

6OAU, 6E7K, 6OAZ, 6OB0

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.744	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014)	0.527	2
UniProt:Q14703 MBTPS1	4	MBTPS1 [Golgi membrane] (R-HSA-381108) MBTPS1 [endoplasmic reticulum membrane] (R-HSA-6797334) p-MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956924) MBTPS1 [endoplasmic reticulum lumen] (R-HSA-8956733)	0.527	3
UniProt:Q96PD2 DCBD2			0.527	2
UniProt:Q9Y4K0 LOXL2	3	LOXL2(26-?) [extracellular region] (R-HSA-2022106) LOXL2 [extracellular region] (R-HSA-2022142) LOXL2(?-774) [extracellular region] (R-HSA-2022136)	0.527	3
UniProt:Q9BWS9 CHID1	2	CHID1 [lysosomal lumen] (R-HSA-8862970) CHID1 [extracellular region] (R-HSA-8862966)	0.527	2
UniProt:O14672 ADAM10	6	ADAM10(214-748) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [specific granule membrane] (R-HSA-6799566) ADAM10 [tertiary granule membrane] (R-HSA-6800992)	0.527	2
UniProt:Q68CR1 SE1L3			0.527	3
UniProt:Q9NZV5 SELN			0.527	3
UniProt:O95158 NXPH4			0.527	2
UniProt:O94985 CSTN1			0.527	2
UniProt:Q86SF2 GALNT7	1	GALNT7 [Golgi membrane] (R-HSA-913624)	0.527	2
UniProt:Q9NYU1 UGGT2	1	UGGT2 [endoplasmic reticulum lumen] (R-HSA-548863)	0.527	2
UniProt:P08069 IGF1R	3	p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180)	0.527	2
UniProt:P12110 COL6A2	20	3x4Hyp-3Hyp-GalHyl-COL6A2(257-1019) [endoplasmic reticulum lumen] (R-HSA-2023552) 3x4Hyp-GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023555) GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187485) GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187483) 3x4Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023675) 3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023643) COL6A2 [endoplasmic reticulum lumen] (R-HSA-1614503) COL6A2 [extracellular region] (R-HSA-2127536) 3x4Hyp-GalHyl-COL6A2 [extracellular region] (R-HSA-2127491) 3x4Hyp-5Hyl-COL6A2 [extracellular region] (R-HSA-2127475) 3x4Hyp-COL6A2 [extracellular region] (R-HSA-2127477) GalHyl-COL6A2 [extracellular region] (R-HSA-2127526) 3x4Hyp-3Hyp-COL6A2 [extracellular region] (R-HSA-2127495) 3x4Hyp-3Hyp-GalHyl-COL6A2 [extracellular region] (R-HSA-2127528) 3x4Hyp-3Hyp-5Hyl-COL6A2 [extracellular region] (R-HSA-2127498) 5Hyl-COL6A2 [extracellular region] (R-HSA-2127467) 3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127500) 3x4Hyp-GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127502) GlcGalHyl-COL6A2 [extracellular region] (R-HSA-2127470) 3x4Hyp-3Hyp-COL6A2(?-1019) [extracellular region] (R-HSA-2470181)	0.527	3
UniProt:Q96AE7 TTC17			0.527	3

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