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p-Y-PLXNB1 [plasma membrane]
Stable Identifier
R-HSA-419609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phosphorylated Plexin B1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:Met (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p190RhoGAP binds Plexin-B1 (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43157 PLXNB1
Gene Names
PLXNB1, KIAA0407, PLXN5, SEP
Chain
signal peptide:1-19, chain:20-2135
Reference Genes
BioGPS Gene:5364 PLXNB1
COSMIC (genes):PLXNB1 PLXNB1
CTD Gene:5364 PLXNB1
dbSNP Gene:5364 PLXNB1
ENSEMBL:ENSG00000164050 PLXNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000164050.13 PLXNB1
HGNC:9103 PLXNB1
KEGG Gene (Homo sapiens):5364 PLXNB1
Monarch:5364 PLXNB1
NCBI Gene:5364 PLXNB1
OMIM:601053 PLXNB1
UCSC:O43157 PLXNB1
Reference Transcript
RefSeq:NM_002673.5 PLXNB1
RefSeq:XM_017006631.1 PLXNB1
RefSeq:NM_001130082.2 PLXNB1
Other Identifiers
11749426_a_at
11754713_a_at
16953329
215668_PM_s_at
215668_s_at
215807_PM_s_at
215807_s_at
2673183
2673184
2673185
2673186
2673188
2673191
2673192
2673194
2673197
2673198
2673200
2673201
2673203
2673205
2673206
2673207
2673208
2673209
2673210
2673211
2673212
2673213
2673214
2673215
2673216
2673217
2673220
2673221
2673222
2673224
2673225
2673226
2673227
2673228
2673229
2673230
2673231
2673232
2673233
2673234
2673235
2673236
2673237
2673238
2673239
2673240
2673241
2673243
2673244
2673245
2673246
2673248
2673249
2673250
2673251
2673252
2673253
2673255
2673256
33783_at
5364
8086908
A_23_P57961
GE81179
GO:0002116
GO:0004888
GO:0005096
GO:0005515
GO:0005576
GO:0005886
GO:0007010
GO:0007155
GO:0007162
GO:0008360
GO:0016020
GO:0016477
GO:0017154
GO:0023052
GO:0030154
GO:0030215
GO:0030334
GO:0032794
GO:0033689
GO:0034330
GO:0035025
GO:0035556
GO:0043547
GO:0043931
GO:0048812
GO:0048856
GO:0048870
GO:0050772
GO:0051493
GO:0051897
GO:0060089
GO:0071526
GO:0098772
GO:1902287
GO:1904862
HMNXSV003001085
Hs.278311.1.S1_3p_a_at
Hs.312939.0.S1_3p_s_at
ILMN_1742330
PH_hs_0014265
TC03001378.hg
X87904_at
Participates
as a component of
MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PLXNB1 [plasma membrane]
Inferred To
phospho-PLXNB1 [plasma membrane]
(Bos taurus)
phospho-PLXNB1 [plasma membrane]
(Canis familiaris)
phospho-PLXNB1 [plasma membrane]
(Sus scrofa)
phospho-p-Y-PLXNB1 [plasma membrane]
(Gallus gallus)
phospho-plxnb1b [plasma membrane]
(Danio rerio)
phospho-PlexB [plasma membrane]
(Drosophila melanogaster)
phospho-Plxnb1 [plasma membrane]
(Mus musculus)
phospho-Plxnb1 [plasma membrane]
(Rattus norvegicus)
phospho-plxnb1 [plasma membrane]
(Xenopus tropicalis)
phospho-plx-2 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_016862120.1
,
NP_001123554.1
,
NP_002664.2
OpenTargets
ENSG00000164050
HPA
ENSG00000164050-PLXNB1
GeneCards
O43157
Ensembl
ENST00000358536
,
ENST00000449094
,
ENSP00000414199
,
ENST00000456774
,
ENSP00000351338
,
ENSP00000395987
,
ENSG00000164050
,
ENST00000296440
,
ENSP00000296440
PRO
O43157
Pharos - Targets
O43157
PDB
5B4W
,
2R2O
,
8B3K
,
3SU8
,
2REX
,
3SUA
,
3OL2
,
3HM6
,
7VF3
,
2OS6
,
7VG7
,
2JPH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92730 RND1
1
RND1 [plasma membrane]
(R-HSA-396949)
0.775
5
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.775
9
UniProt:P61587 RND3
1
RND3 [plasma membrane]
(R-HSA-9696265)
0.676
3
UniProt:P52198 RND2
1
RND2 [plasma membrane]
(R-HSA-9696269)
0.558
2
UniProt:Q04912 MST1R
3
p-Y1238,1239,1353,1360-MST1R (310-1400) [plasma membrane]
(R-HSA-8852533)
MST1R (310-1400) [plasma membrane]
(R-HSA-6800308)
MST1R (25-304) [plasma membrane]
(R-HSA-6800303)
0.524
3
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