ATP6AP1 binds V-ATPase

Stable Identifier
Reaction [binding]
Homo sapiens
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Vacuolar-type H+-ATPases (V-ATPases) are proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of many specialised cells. V-type proton ATPase subunit S1 (ATP6AP1) is thought to function as an accessory subunit of the V0 subcomplex of V-ATPase, facilitating acidification (Supek et al. 1994). Experiments with the mouse orthologue reveals a role for Atp6ap1 in osteoclast formation and function (Qin et al. 2011).

Literature References
PubMed ID Title Journal Year
7929063 A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules

Supek, F, Supekova, L, Mandiyan, S, Pan, YC, Nelson, H, Nelson, N

J. Biol. Chem. 1994
22087256 Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function

Qin, A, Cheng, TS, Lin, Z, Pavlos, NJ, Jiang, Q, Xu, J, Dai, KR, Zheng, MH

PLoS ONE 2011
Participant Of
Orthologous Events
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