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p-S158,221-HuR binds mRNA
Stable Identifier
R-HSA-517674
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)
p-S158,221-HuR binds mRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HuR (ELAV1) phosphorylated on serine221 and serine158 binds COX-2 mRNA in the nucleus. The phosphorylation of serine 158 appears to affect RNA-binding while phosphorylation on serine 221 affects nucleocytoplasmic shuffling.
Literature References
PubMed ID
Title
Journal
Year
17392515
Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
Pfeilschifter, J
,
Müller, R
,
Doller, A
,
Huwiler, A
,
Eberhardt, W
,
Radeke, HH
Mol Biol Cell
2007
Participants
Input
mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318. [nucleoplasm]
p-S158,S221-ELAVL1 [nucleoplasm]
(Homo sapiens)
Output
HuR with phosphoserine221 and phosphoserine158:mRNA Complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
HuR (ELAVL1) binds and stabilizes mRNA (Homo sapiens)
Orthologous Events
p-S158,221-HuR binds mRNA (Bos taurus)
p-S158,221-HuR binds mRNA (Canis familiaris)
p-S158,221-HuR binds mRNA (Drosophila melanogaster)
p-S158,221-HuR binds mRNA (Gallus gallus)
p-S158,221-HuR binds mRNA (Mus musculus)
p-S158,221-HuR binds mRNA (Rattus norvegicus)
p-S158,221-HuR binds mRNA (Sus scrofa)
p-S158,221-HuR binds mRNA (Xenopus tropicalis)
Authored
May, B (2010-02-18)
Reviewed
Wilusz, J (2010-06-29)
Created
May, B (2010-02-20)
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