Reactome | P2Y receptors

P2Y receptors

Stable Identifier

R-HSA-417957

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans (Abbracchio MP et al, 2006; Fischer W and Krugel U, 2007). P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. Purine nucleotides are involved in a large number of intermediate metabolic pathways, taking part as substrates, products or allosteric factors.

Literature References

PubMed ID	Title	Journal	Year
17979698	P2Y receptors: focus on structural, pharmacological and functional aspects in the brain Fischer, W, Krügel, U	Curr Med Chem	2007
16968944	International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Abbracchio, MP, Burnstock, G, Boeynaems, JM, Barnard, EA, Boyer, JL, Kennedy, C, Knight, GE, Fumagalli, M, Gachet, C, Jacobson, KA, Weisman, GA	Pharmacol Rev	2006