P2Y receptors

Stable Identifier
R-HSA-417957
Type
Pathway
Species
Homo sapiens
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P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans (Abbracchio MP et al, 2006; Fischer W and Krugel U, 2007). P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. Purine nucleotides are involved in a large number of intermediate metabolic pathways, taking part as substrates, products or allosteric factors.

Literature References
PubMed ID Title Journal Year
16968944 International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

Abbracchio, MP, Burnstock, G, Boeynaems, JM, Barnard, EA, Boyer, JL, Kennedy, C, Knight, GE, Fumagalli, M, Gachet, C, Jacobson, KA, Weisman, GA

Pharmacol Rev 2006
17979698 P2Y receptors: focus on structural, pharmacological and functional aspects in the brain

Fischer, W, Kr├╝gel, U

Curr Med Chem 2007
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