Reactome | P2Y receptors

P2Y receptors

Stable Identifier

R-HSA-417957

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans (Abbracchio MP et al, 2006; Fischer W and Krugel U, 2007). P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. Purine nucleotides are involved in a large number of intermediate metabolic pathways, taking part as substrates, products or allosteric factors.

Literature References

PubMed ID	Title	Journal	Year
17979698	P2Y receptors: focus on structural, pharmacological and functional aspects in the brain Krügel, U, Fischer, W	Curr Med Chem	2007
16968944	International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy Kennedy, C, Boyer, JL, Barnard, EA, Jacobson, KA, Knight, GE, Abbracchio, MP, Gachet, C, Burnstock, G, Boeynaems, JM, Weisman, GA, Fumagalli, M	Pharmacol Rev	2006