P2Y receptors

Stable Identifier
R-HSA-417957
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

P2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans (Abbracchio MP et al, 2006; Fischer W and Krugel U, 2007). P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. Purine nucleotides are involved in a large number of intermediate metabolic pathways, taking part as substrates, products or allosteric factors.

Literature References
PubMed ID Title Journal Year
17979698 P2Y receptors: focus on structural, pharmacological and functional aspects in the brain

Kr├╝gel, U, Fischer, W

Curr Med Chem 2007
16968944 International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

Kennedy, C, Boyer, JL, Barnard, EA, Jacobson, KA, Knight, GE, Abbracchio, MP, Gachet, C, Burnstock, G, Boeynaems, JM, Weisman, GA, Fumagalli, M

Pharmacol Rev 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!