Reactome | P2Y11 receptor can bind to ATP

P2Y11 receptor can bind to ATP

Stable Identifier

R-HSA-417825

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y11 receptor can bind to ATP (Homo sapiens)

General

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The P2Y11 receptor (Communi D et al, 1997) can bind adenosine nucleotides but not uridine nucleotides. This receptor is coupled to the stimulation of both the phosphoinositide (Gq/11) and adenylyl cyclase (Gs) pathways (Qi AD et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11156592	Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase Qi, AD, Kennedy, C, Harden, TK, Nicholas, RA	Br J Pharmacol	2001
9405388	Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase Communi, D, Govaerts, C, Parmentier, M, Boeynaems, JM	J Biol Chem	1997

Participants

Input

Output

P2RY11 :ATP [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

P2Y receptors

Orthologous Events

P2Y11 receptor can bind to ATP (Bos taurus)

P2Y11 receptor can bind to ATP (Danio rerio)

P2Y11 receptor can bind to ATP (Sus scrofa)

P2Y11 receptor can bind to ATP (Xenopus tropicalis)

Authored

Jassal, B (2009-04-14)

Reviewed

D'Eustachio, P (2009-05-29)

Created

Jassal, B (2009-04-14)