Reactome | P2Y11 receptor can bind to ATP

P2Y11 receptor can bind to ATP

Stable Identifier

R-HSA-417825

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y11 receptor can bind to ATP (Homo sapiens)

Summation

The P2Y11 receptor (Communi D et al, 1997) can bind adenosine nucleotides but not uridine nucleotides. This receptor is coupled to the stimulation of both the phosphoinositide (Gq/11) and adenylyl cyclase (Gs) pathways (Qi AD et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11156592	Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase Qi, AD, Kennedy, C, Harden, TK, Nicholas, RA	Br J Pharmacol	2001
9405388	Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase Communi, D, Govaerts, C, Parmentier, M, Boeynaems, JM	J Biol Chem	1997