P2Y2 receptor binds ATP and UTP

Stable Identifier
R-HSA-417927
Type
Reaction
Species
Homo sapiens
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The P2Y2 receptor (Parr CE et al, 1994) is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene. The effects of P2Y2 are mediated by coupling with the G protein alpha Gq/11 subunits (Schachter JB et al, 1997). P2Y2 is a potential drug target for treating cystic fibrosis (Kellerman D et al, 2002).

Literature References
PubMed ID Title Journal Year
9364473 HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors

Nicholas, RA, Harden, TK, Sromek, SM, Schachter, JB

Neuropharmacology 1997
12458155 Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease

Kellerman, D, Shaffer, C, Mathews, D, Evans, R

Adv Drug Deliv Rev 2002
8159738 Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy

Turner, JT, Erb, L, Olsen, JC, Burch, LH, Lazarowski, ER, Parr, CE, Weisman, GA, Paradiso, AM, Boucher, RC, Sullivan, DM

Proc Natl Acad Sci U S A 1994
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