Reactome | P2Y9 receptor can bind to LPA

P2Y9 receptor can bind to LPA

Stable Identifier

R-HSA-417820

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y9 receptor can bind to LPA (Homo sapiens)

General

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The human form of the receptor was cloned and sequenced as GPR23 (Janssens R et al, 1997). P2Y9 has been reported to bind lysophosphatidic acid (LPA) as a ligand and elicit numerous effects via multiple G proteins (Lee CW et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
17166850	LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation Lee, CW, Rivera, R, Dubin, AE, Chun, J	J Biol Chem	2007
9223435	Cloning of a human heptahelical receptor closely related to the P2Y5 receptor Janssens, R, Boeynaems, JM, Godart, M, Communi, D	Biochem Biophys Res Commun	1997