P2RY1 binds ADP

Stable Identifier
R-HSA-417908
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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P2RY1 binds ADP (Leon et al. 1996). It is one of two platelet ADP receptors, the other is P2RY12, that initiate platelet activation when stimulated in concert. P2RY1 signals through Gq, while P2Y12 signals through Gi. This results in mobilization of intracellular calcium ions via activation of phospholipase C, which leads to a change in platelet shape and probably to platelet aggregation (Schachter et al. 1997).

Literature References
PubMed ID Title Journal Year
9364473 HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors

Schachter, JB, Sromek, SM, Nicholas, RA, Harden, TK

Neuropharmacology 1997
8666290 Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor

Léon, C, Vial, C, Cazenave, JP, Gachet, C

Gene 1996
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