Reactome | P2RY1 binds ADP

P2RY1 binds ADP

Stable Identifier

R-HSA-417908

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2RY1 binds ADP (Homo sapiens)

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P2RY1 binds ADP (Leon et al. 1996). It is one of two platelet ADP receptors, the other is P2RY12, that initiate platelet activation when stimulated in concert. P2RY1 signals through Gq, while P2Y12 signals through Gi. This results in mobilization of intracellular calcium ions via activation of phospholipase C, which leads to a change in platelet shape and probably to platelet aggregation (Schachter et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8666290	Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor Vial, C, Léon, C, Gachet, C, Cazenave, JP	Gene	1996
9364473	HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors Nicholas, RA, Harden, TK, Sromek, SM, Schachter, JB	Neuropharmacology	1997