Reactome | P2Y14 receptor can bind to UDP-glucose

P2Y14 receptor can bind to UDP-glucose

Stable Identifier

R-HSA-417858

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y14 receptor can bind to UDP-glucose (Homo sapiens)

General

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Uridine 5'-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of glycogen and polysaccharides. UDP-glucose may also possess pharmacological activity and is found to activate the orphan receptor P2Y14 (KIAA0001) (Chambers JK et al, 2000). Nucleotides known to activate P2Y receptors were inactive towards P2Y14. This receptor's actions are mediated by coupling with the G protein alpha Gi/o which inhibits adenylyl cyclase and thus, reduces cAMP accumulation (Fricks IP et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19339661	Gi-dependent cell signaling responses of the human P2Y14-receptor in model cell systems Lazarowski, ER, Carter, RL, Harden, TK, Fricks, IP	J Pharmacol Exp Ther	2009
10753868	A G protein-coupled receptor for UDP-glucose McMillan, L, Murphy, AJ, Naheed, S, Freeman, K, Murdock, P, Bergsma, DJ, Wilson, S, Aiyar, N, Taylor, P, Sarau, HM, Duzic, E, Vawter, L, Watson, JM, Swift, A, Zhu, Y, Macdonald, LE, Hervieu, G, McLaughlin, MM, Livi, GP, Ames, RS, Trill, J, Scott, C, Szekeres, P, Foley, JJ, Chambers, JK, Klein, C	J Biol Chem	2000