P2Y14 receptor can bind to UDP-glucose

Stable Identifier
Homo sapiens
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Uridine 5'-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of glycogen and polysaccharides. UDP-glucose may also possess pharmacological activity and is found to activate the orphan receptor P2Y14 (KIAA0001) (Chambers JK et al, 2000). Nucleotides known to activate P2Y receptors were inactive towards P2Y14. This receptor's actions are mediated by coupling with the G protein alpha Gi/o which inhibits adenylyl cyclase and thus, reduces cAMP accumulation (Fricks IP et al, 2009).

Literature References
PubMed ID Title Journal Year
19339661 Gi-dependent cell signaling responses of the human P2Y14-receptor in model cell systems

Lazarowski, ER, Carter, RL, Harden, TK, Fricks, IP

J Pharmacol Exp Ther 2009
10753868 A G protein-coupled receptor for UDP-glucose

McMillan, L, Murphy, AJ, Naheed, S, Freeman, K, Murdock, P, Bergsma, DJ, Wilson, S, Aiyar, N, Taylor, P, Sarau, HM, Duzic, E, Vawter, L, Watson, JM, Swift, A, Zhu, Y, Macdonald, LE, Hervieu, G, McLaughlin, MM, Livi, GP, Ames, RS, Trill, J, Scott, C, Szekeres, P, Foley, JJ, Chambers, JK, Klein, C

J Biol Chem 2000
Orthologous Events
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