Reactome | P2Y10 receptor can bind to LPA

P2Y10 receptor can bind to LPA

Stable Identifier

R-HSA-417842

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y10 receptor can bind to LPA (Homo sapiens)

General

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The P2Y10 receptor is expressed during myeloid differentiation of HL60 cells (Adrian K et al, 2000) and is the first dual lysophospholipid receptor, able to bind both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) (Murakami M et al, 2008). The effects of this receptor are mediated by coupling with the G protein alpha q/11 subunit.

Literature References

PubMed ID	Title	Journal	Year
11004484	Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells Adrian, K, Bernhard, MK, Breitinger, HG, Ogilvie, A	Biochim Biophys Acta	2000
18466763	Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor Murakami, M, Shiraishi, A, Tabata, K, Fujita, N	Biochem Biophys Res Commun	2008