P2Y10 receptor can bind to LPA

Stable Identifier
R-HSA-417842
Type
Reaction
Species
Homo sapiens
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The P2Y10 receptor is expressed during myeloid differentiation of HL60 cells (Adrian K et al, 2000) and is the first dual lysophospholipid receptor, able to bind both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) (Murakami M et al, 2008). The effects of this receptor are mediated by coupling with the G protein alpha q/11 subunit.

Literature References
PubMed ID Title Journal Year
11004484 Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells

Adrian, K, Ogilvie, A, Breitinger, HG, Bernhard, MK

Biochim Biophys Acta 2000
18466763 Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor

Murakami, M, Shiraishi, A, Tabata, K, Fujita, N

Biochem Biophys Res Commun 2008
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