Reactome | P2Y5 receptor can bind to LPA

P2Y5 receptor can bind to LPA

Stable Identifier

R-HSA-417890

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y5 receptor can bind to LPA (Homo sapiens)

General

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The P2Y5 receptor (Lee CW et al, 2006) binds lysophosphatidic acid (LPA). Its effects are mediated by coupling with the G protein alpha G q/11 and G12/13 subunits (Lee CW et al, 2006). Mutations in the P2RY5 gene cause a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth (Pasternack SM et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
16774927	GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5 Lee, CW, Rivera, R, Gardell, S, Dubin, AE, Chun, J	J Biol Chem	2006
18297070	G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth Pasternack, SM, von Kügelgen, I, Aboud, KA, Lee, YA, Rüschendorf, F, Voss, K, Hillmer, AM, Molderings, GJ, Franz, T, Ramirez, A, Nürnberg, P, Nöthen, MM, Betz, RC	Nat Genet	2008