The P2Y5 receptor (Lee CW et al, 2006) binds lysophosphatidic acid (LPA). Its effects are mediated by coupling with the G protein alpha G q/11 and G12/13 subunits (Lee CW et al, 2006). Mutations in the P2RY5 gene cause a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth (Pasternack SM et al, 2008).
Voss, K, Hillmer, AM, Lee, YA, Rüschendorf, F, Nöthen, MM, Franz, T, von Kügelgen, I, Ramirez, A, Pasternack, SM, Molderings, GJ, Betz, RC, Aboud, KA, Nürnberg, P
Lee, CW, Gardell, S, Dubin, AE, Chun, J, Rivera, R
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