P2Y5 receptor can bind to LPA

Stable Identifier
R-HSA-417890
Type
Reaction [binding]
Species
Homo sapiens
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The P2Y5 receptor (Lee CW et al, 2006) binds lysophosphatidic acid (LPA). Its effects are mediated by coupling with the G protein alpha G q/11 and G12/13 subunits (Lee CW et al, 2006). Mutations in the P2RY5 gene cause a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth (Pasternack SM et al, 2008).

Literature References
PubMed ID Title Journal Year
16774927 GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5

Lee, CW, Rivera, R, Gardell, S, Dubin, AE, Chun, J

J Biol Chem 2006
18297070 G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Pasternack, SM, von Kügelgen, I, Aboud, KA, Lee, YA, Rüschendorf, F, Voss, K, Hillmer, AM, Molderings, GJ, Franz, T, Ramirez, A, Nürnberg, P, Nöthen, MM, Betz, RC

Nat Genet 2008
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