Reactome | P2Y6 receptor can bind to UDP

P2Y6 receptor can bind to UDP

Stable Identifier

R-HSA-417896

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        P2Y6 receptor can bind to UDP (Homo sapiens)

General

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The P2Y6 receptor (Communi D et al, 1996) is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene. The effects of P2Y6 are mediated by coupling to stimulation of both the phosphoinositide and adenylyl cyclase pathways, a unique feature among the P2Y family (Communi D et al,1997).

Literature References

PubMed ID	Title	Journal	Year
9405388	Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase Communi, D, Govaerts, C, Parmentier, M, Boeynaems, JM	J Biol Chem	1997
8670200	Cloning, functional expression and tissue distribution of the human P2Y6 receptor Communi, D, Parmentier, M, Boeynaems, JM	Biochem Biophys Res Commun	1996