The UDP/CysLT (P2Y17) receptor can bind UTP

Stable Identifier
R-HSA-418918
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GPR17, an orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In this example, GPR17 binds to UDP. The UDP-bound receptor couples with Gq/11 and leads to intracellular calcium increases (Ciana P et al, 2006).

Literature References
PubMed ID Title Journal Year
16990797 The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor

Ciana, P, Fumagalli, M, Trincavelli, ML, Verderio, C, Rosa, P, Lecca, D, Ferrario, S, Parravicini, C, Capra, V, Gelosa, P, Guerrini, U, Belcredito, S, Cimino, M, Sironi, L, Tremoli, E, Rovati, GE, Martini, C, Abbracchio, MP

EMBO J 2006
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