Reactome | The UDP/CysLT (P2Y17) receptor can bind UTP

The UDP/CysLT (P2Y17) receptor can bind UTP

Stable Identifier

R-HSA-418918

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        P2Y receptors (Homo sapiens)
        
        The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)

General

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The UDP/CysLT (P2Y17) receptor can bind UTP

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GPR17, an orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In this example, GPR17 binds to UDP. The UDP-bound receptor couples with Gq/11 and leads to intracellular calcium increases (Ciana P et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16990797	The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor Tremoli, E, Sironi, L, Ciana, P, Gelosa, P, Trincavelli, ML, Cimino, M, Parravicini, C, Abbracchio, MP, Guerrini, U, Lecca, D, Fumagalli, M, Capra, V, Martini, C, Rovati, GE, Belcredito, S, Verderio, C, Ferrario, S, Rosa, P	EMBO J	2006