Expression of CEBPB in adipogenesis

Stable Identifier
R-HSA-381337
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of CEBPB in adipogenesis
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As inferred from mouse, EGF2 (KROX20) together with KLF4 bind the promoter of the CEBPB gene and activate transcription. As inferred from mouse, KLF4 together with EGF2 (KROX20) bind the promoter of the CEBPB gene and activate transcription. Expression of the CEBPB and CEBPD transcription factors is induced by at least three factors:
1) Mitogens such as those present in fetal serum act via the Krox20 transcription factor to activate expression of CEBPB.
2) Glucocorticoids activate expression of CEBPD.
3) Hormones or drugs that increase intracellular cAMP act via pCREB to activate expression of CEBPB.
The detailed mechanisms of activation are not yet known.
Literature References
PubMed ID Title Journal Year
17011499 Transcriptional control of adipocyte formation

Farmer, SR

Cell Metab 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EGR2 [nucleoplasm] (Homo sapiens)
Regulator
KLF4 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Cebpb (Mus musculus)
Authored
May, B  (2009-05-15)
Reviewed
Sethi, JK  (2011-02-10)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2008-11-20)
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