Expression of CEBPB in response to stress

Stable Identifier
R-HSA-9635918
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of CEBPB in response to stress
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The CEBPB gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Chen et al. 2005, Lee et al. 2008, Sikalidis et al. 2011). Transcription of CEBPB is activated in response to amino acid deficiency (Chen et al. 2005, Lee et al. 2008, Sikalidis et al. 2011). ATF4 bound to an enhancer downstream of the CEBPB coding region (Chen et al. 2005) increases transcription of CEBPB approximately 4-fold (Chen et al. 2005, Lee et al. 2008, Sikalidis et al. 2011).
Literature References
PubMed ID Title Journal Year
18285520 HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway

Dominy, JE, Sikalidis, AK, Lee, JI, Stipanuk, MH, Hirschberger, LL, Wang, W

Physiol. Genomics 2008
16026328 Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence

Kilberg, MS, Gjymishka, A, Pan, YX, Dudenhausen, E, Chen, C, Chen, H

Biochem. J. 2005
20361218 Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

Sikalidis, AK, Lee, JI, Stipanuk, MH

Amino Acids 2011
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
ATF4:CEBPB gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2019-02-09)
Reviewed
Staschke, KA  (2019-11-20)
Bruhat, A  (2019-09-15)
Created
May, B  (2019-02-10)
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