Expression of Adiponectin

Stable Identifier
R-HSA-1183058
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Adiponectin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Adiponectin gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of Adiponectin is upregulated during adipogenesis by C/EBPalpha (CEBPA), PPARG, and CEBPB (Segawa et al. 2009, Qiao et al. 2005, Iwaki et al. 2003, Kita et al. 2005).

Literature References
PubMed ID Title Journal Year
15850785 Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha

Kita, A, Yamasaki, H, Kuwahara, H, Moriuchi, A, Fukushima, K, Kobayashi, M, Fukushima, T, Takahashi, R, Abiru, N, Uotani, S, Kawasaki, E, Eguchi, K

Biochem Biophys Res Commun 2005
18931025 Identification of a novel distal enhancer in human adiponectin gene

Segawa, K, Matsuda, M, Fukuhara, A, Morita, K, Okuno, Y, Komuro, R, Shimomura, I

J Endocrinol 2009
15919796 C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer

Qiao, L, Maclean, PS, Schaack, J, Orlicky, DJ, Darimont, C, Pagliassotti, M, Friedman, JE, Shao, J

Diabetes 2005
12829629 Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors

Iwaki, M, Matsuda, M, Maeda, N, Funahashi, T, Matsuzawa, Y, Makishima, M, Shimomura, I

Diabetes 2003
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
May, B  (2011-02-08)
Reviewed
D'Eustachio, P  (2009-05-27)
Sethi, JK  (2011-02-10)
Created
May, B  (2011-02-10)