Expression of Adiponectin

Stable Identifier
R-HSA-1183058
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of Adiponectin
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C/EBPbeta (CEBPB) binds the promoter of the Adiponectin gene and activates transcription. The PPARG:RXRA heterodimer activated by a thiazolidinedione agonist binds the promoter of the Adiponectin gene and activates transcription. The Adiponectin gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Expression of Adiponectin is upregulated during adipogenesis by C/EBPalpha (CEBPA), PPARG, and CEBPB (Segawa et al. 2009, Qiao et al. 2005, Iwaki et al. 2003, Kita et al. 2005). C/EBPalpha (CEBPA) binds the promoter of the Adiponectin gene and activates transcription.
Literature References
PubMed ID Title Journal Year
18931025 Identification of a novel distal enhancer in human adiponectin gene

Segawa, K, Matsuda, M, Fukuhara, A, Morita, K, Okuno, Y, Komuro, R, Shimomura, I

J Endocrinol 2009
15850785 Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha

Kita, A, Yamasaki, H, Kuwahara, H, Moriuchi, A, Fukushima, K, Kobayashi, M, Fukushima, T, Takahashi, R, Abiru, N, Uotani, S, Kawasaki, E, Eguchi, K

Biochem Biophys Res Commun 2005
15919796 C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer

Qiao, L, Maclean, PS, Schaack, J, Orlicky, DJ, Darimont, C, Pagliassotti, M, Friedman, JE, Shao, J

Diabetes 2005
12829629 Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors

Iwaki, M, Matsuda, M, Maeda, N, Funahashi, T, Matsuzawa, Y, Makishima, M, Shimomura, I

Diabetes 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Regulator
CEBPB [nucleoplasm] (Homo sapiens)
Regulator
CEBPA [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-02-08)
Reviewed
D'Eustachio, P  (2009-05-27)
Sethi, JK  (2011-02-10)
Created
May, B  (2011-02-10)
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