Activated STAT3 positively regulates CEBPB transcription

Stable Identifier
R-HSA-3858387
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
STAT3, activated by IL6 signaling cascade, is necessary for CEBPB transcription, but direct binding of STAT3 to the CEBPB promoter has not been demonstrated (Niehof et al. 2001). As CEBPB activates IL6 transcription in response to oncogenic RAS signaling, and IL6 activates CEBPB transcription (Niehof et al. 2001, Kuilman et al. 2008, Lee et al. 2010), a positive feedback loop exists between CEBPB and IL6.
Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Shuman, JD, Cohen, MS, Sakchaisri, K, Taunton, J, Lee, S, Sebastian, T, Smart, RC, Veenstra, TD, Xiao, Z, Yu, LR, Miller, M, Copeland, TD, Guszczynski, T, Johnson, PF

Mol. Cell. Biol. 2010
18555778 Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

Kuilman, T, Mooi, WJ, Douma, S, Aarden, LA, van Doorn, R, Michaloglou, C, Peeper, DS, Vredeveld, LC, Desmet, CJ

Cell 2008
11114305 Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3

Bischoff, SC, Streetz, K, Horn, F, Rakemann, T, Manns, MP, Trautwein, C, Niehof, M

J. Biol. Chem. 2001
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!