Activated STAT3 positively regulates CEBPB transcription

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Reaction [omitted]
Homo sapiens
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STAT3, activated by IL6 signaling cascade, is necessary for CEBPB transcription, but direct binding of STAT3 to the CEBPB promoter has not been demonstrated (Niehof et al. 2001). As CEBPB activates IL6 transcription in response to oncogenic RAS signaling, and IL6 activates CEBPB transcription (Niehof et al. 2001, Kuilman et al. 2008, Lee et al. 2010), a positive feedback loop exists between CEBPB and IL6.

Literature References
PubMed ID Title Journal Year
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Shuman, JD, Cohen, MS, Sakchaisri, K, Taunton, J, Lee, S, Sebastian, T, Smart, RC, Veenstra, TD, Xiao, Z, Yu, LR, Miller, M, Copeland, TD, Guszczynski, T, Johnson, PF

Mol. Cell. Biol. 2010
18555778 Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

Kuilman, T, Mooi, WJ, Douma, S, Aarden, LA, van Doorn, R, Michaloglou, C, Peeper, DS, Vredeveld, LC, Desmet, CJ

Cell 2008
11114305 Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3

Bischoff, SC, Streetz, K, Horn, F, Rakemann, T, Manns, MP, Trautwein, C, Niehof, M

J. Biol. Chem. 2001
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