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HMGA1 [nucleoplasm]
Stable Identifier
R-HSA-3004623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
High mobility group protein HMG-I/HMG-Y, HMGA1_HUMAN, HMGI/Y
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
SAHF formation (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
SAHF [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
1-LTR circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
viral PIC proteins [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
2-LTR circle formation (Homo sapiens)
Association of Ku heterodimer with viral DNA ends (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
viral PIC proteins [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
Autointegration results in viral DNA circles (Homo sapiens)
Suicidal integration leading to inverted circle formation (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
viral PIC proteins [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
viral PIC proteins [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
Import of PIC to the Host Nucleus (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
Integration of viral DNA into host genomic DNA (Homo sapiens)
Target DNA binding (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
viral PIC proteins [nucleoplasm] (Homo sapiens)
HMGA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17096 HMGA1
Gene Names
HMGA1, HMGIY
Chain
initiator methionine:, chain:2-107
Reference Genes
BioGPS Gene:3159 HMGA1
COSMIC (genes):HMGA1 HMGA1
CTD Gene:3159 HMGA1
dbSNP Gene:3159 HMGA1
ENSEMBL:ENSG00000137309 HMGA1
ENSEMBL_homo_sapiens_GENE:ENSG00000137309.21 HMGA1
HGNC:5010 HMGA1
KEGG Gene (Homo sapiens):3159 HMGA1
Monarch:3159 HMGA1
NCBI Gene:3159 HMGA1
OMIM:600701 HMGA1
UCSC:P17096 HMGA1
Reference Transcript
RefSeq:NM_145899.2 HMGA1
RefSeq:NM_001319077.1 HMGA1
RefSeq:NM_001319079.1 HMGA1
RefSeq:NM_145902.2 HMGA1
RefSeq:NM_001319081.1 HMGA1
RefSeq:NM_002131.3 HMGA1
RefSeq:NM_145905.2 HMGA1
RefSeq:NM_145901.2 HMGA1
RefSeq:NM_145903.2 HMGA1
RefSeq:NM_001319078.1 HMGA1
RefSeq:NM_001319080.1 HMGA1
RefSeq:NM_001319082.1 HMGA1
Other Identifiers
11747361_x_at
11753571_x_at
11753817_x_at
17007620
17117871
206074_3p_s_at
206074_PM_s_at
206074_s_at
210457_3p_x_at
210457_PM_x_at
210457_x_at
2904044
2904045
2904046
2904047
2904048
2904049
2904051
2904054
2904055
2904056
2904057
2904058
2904060
2904066
2904067
2904068
2904069
2904070
2904079
3159
3471201
39704_s_at
3972433
64363_f_at
8118794
8180307
8180308
A_23_P42331
A_24_P222043
GE659143
GO:0000785
GO:0000978
GO:0000987
GO:0001221
GO:0003677
GO:0003680
GO:0003682
GO:0003712
GO:0003713
GO:0003723
GO:0003824
GO:0003906
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005829
GO:0005925
GO:0006260
GO:0006268
GO:0006281
GO:0006284
GO:0006325
GO:0006337
GO:0006351
GO:0006355
GO:0008285
GO:0008301
GO:0010468
GO:0010604
GO:0016829
GO:0019899
GO:0030374
GO:0030527
GO:0035985
GO:0042974
GO:0042975
GO:0043226
GO:0045892
GO:0045893
GO:0045944
GO:0046965
GO:0051575
GO:0060090
GO:0090402
GO:0090575
GO:0098772
GO:0140097
GO:0140110
GO:0140677
HMNXSV003015779
ILMN_1693560
ILMN_1742699
ILMN_2311537
L17131_rna1_at
PH_hs_0034458
TC06000501.hg
TC06002746.hg
g4504432_3p_s_at
g4504432_3p_x_at
g5834272_3p_s_at
Participates
as a component of
viral PIC proteins [nucleoplasm] (Homo sapiens)
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm] (Homo sapiens)
SAHF [nucleoplasm] (Homo sapiens)
as an input of
SAHF formation (Homo sapiens)
Other forms of this molecule
HMGA1 [cytosol]
Inferred To
HMGA1 [nucleoplasm]
(Canis familiaris)
HMGA1 [nucleoplasm]
(Sus scrofa)
hmg-12 [nucleoplasm]
(Caenorhabditis elegans)
Hmga1 [nucleoplasm]
(Mus musculus)
Cross References
RefSeq
NP_001306006.1
,
NP_002122.1
,
NP_001306008.1
,
NP_001306007.1
,
NP_001306010.1
,
NP_001306011.1
,
NP_665909.1
,
NP_665910.1
,
NP_001306009.1
,
NP_665912.1
,
NP_665908.1
,
NP_665906.1
OpenTargets
ENSG00000137309
HPA
ENSG00000137309-HMGA1
GeneCards
P17096
Ensembl
ENSP00000399888
,
ENST00000374116
,
ENST00000347617
,
ENSP00000288245
,
ENSG00000137309
,
ENSP00000308227
,
ENST00000447654
,
ENST00000311487
,
ENSP00000385693
,
ENSP00000363230
,
ENST00000401473
PRO
P17096
Pharos - Targets
P17096
PDB
2EZE
,
2EZD
,
2EZF
,
2EZG
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IUE6 H2AC21
11
AcK-HIST2H2AB [nucleoplasm]
(R-HSA-4551335)
HIST2H2AB [nucleoplasm]
(R-HSA-4549212)
MeR12-HIST2H2AB [nucleoplasm]
(R-HSA-5229207)
Me2aR12-HIST2H2AB [nucleoplasm]
(R-HSA-5229314)
MeR4-HIST2H2AB [nucleoplasm]
(R-HSA-5244632)
Me2aR4-HIST2H2AB [nucleoplasm]
(R-HSA-5244588)
MeR30-HIST2H2AB [nucleoplasm]
(R-HSA-5244540)
Me2aR30-HIST2H2AB [nucleoplasm]
(R-HSA-5244567)
AcK6-HIST2H2AB [nucleoplasm]
(R-HSA-4568609)
Ub-HIST2H2AB [nucleoplasm]
(R-HSA-6782490)
K63polyUb-HIST2H2AB [nucleoplasm]
(R-HSA-6783295)
0.669
3
UniProt:Q9Y5N6 ORC6
4
ORC6 [nucleoplasm]
(R-HSA-68539)
ORC6 [cytosol]
(R-HSA-9734663)
p-T195-ORC6 [cytosol]
(R-HSA-9734682)
p-T195-ORC6 [nucleoplasm]
(R-HSA-9734715)
0.602
4
UniProt:P16402 H1-3
1
HIST1H1D [nucleoplasm]
(R-HSA-211241)
0.564
2
UniProt:Q16778 H2BC21
9
Ub-HIST2H2BE [nucleoplasm]
(R-HSA-6782539)
Ack-HIST2H2BE [nucleoplasm]
(R-HSA-4549257)
HIST2H2BE [extracellular region]
(R-HSA-977571)
AcK13-HIST2H2BE [nucleoplasm]
(R-HSA-4568651)
AcK21-HIST2H2BE [nucleoplasm]
(R-HSA-4568716)
AcK6-HIST2H2BE [nucleoplasm]
(R-HSA-4568679)
AcK16-HIST2H2BE [nucleoplasm]
(R-HSA-4568660)
Ub-121-HIST2H2BE [nucleoplasm]
(R-HSA-3364018)
HIST2H2BE [nucleoplasm]
(R-HSA-181908)
0.564
2
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.564
2
UniProt:P17676 CEBPB
3
p-T235, S321-CEBPB [nucleoplasm]
(R-HSA-3857339)
p-T235-CEBPB [nucleoplasm]
(R-HSA-3857343)
CEBPB [nucleoplasm]
(R-HSA-381378)
0.544
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.544
4
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.527
2
UniProt:O75367 H2AY
0.527
2
IntAct:EBI-1566868 IL2RA
0.525
3
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