NPM1-ALK-dependent CEBPB gene expression

Stable Identifier
R-HSA-9725357
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NPM1-ALK-dependent CEBPB gene expression
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CEBPB is a transcription factor with roles in immune and inflammatory reponses that was identified as a target of NPM-ALK signaling downstream of STAT3 and MAPK1/3 (Piva et al, 2006; Quintanilla-Martinez et al, 2006; Anastasov et al, 2010). CEBPB expression is downregulated after treatment of cells with anti-NPM-ALK RNAi or shRNA. CEBPB expression downstream of NPM-ALK signaling promotes cellular survival, as its knockdown increases the proportion of cells undergoing apoptosis. In mouse models of NPM-ALK, CEBPB is required for entry into S phase and contributes to the transforming properties of the fusion protein. (Piva et al, 2006; Quintanilla-Martinez et al, 2006; Anastasov et al, 2010; reviewed in Hallberg and Palmer, 2013).
Literature References
PubMed ID Title Journal Year
17111047 Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes

Chiarle, R, Piva, R, Inghirami, G, Ruggeri, BA, Boccalatte, F, Cheng, M, Palestro, G, Costa, G, Lombardi, L, Pellegrino, E, Neri, A, Agnelli, L, Mattioli, M

J Clin Invest 2006
20015877 C/EBPβ expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway

Anastasov, N, Raffeld, M, Klier, M, Fend, F, Duyster, J, Dau, T, Angermeier, D, Bonzheim, I, Rudelius, M, Quintanilla-Martinez, L, Pittaluga, S

Haematologica 2010
16709933 NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma

Anastasov, N, Raffeld, M, Klier, M, Fend, F, Duyster, J, Rudelius, M, Quintanilla-Martinez, L, Pittaluga, S, Martinez, A, Miething, C, Davies-Hill, T, Vivero, A, Jaffe, ES

Blood 2006
24060861 Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

Palmer, RH, Hallberg, B

Nat. Rev. Cancer 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm] (Homo sapiens)
Regulator
p-T,Y MAPK monomers and dimers [nucleoplasm] (Homo sapiens)
Regulator
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2021-03-29)
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