1,25(OH)2D binds VDR

Stable Identifier
R-HSA-8963915
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The biologically active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D), interacts with the nuclear hormone receptor vitamin D receptor (VDR) in the nucleoplasm of any target tissue (Neme et al. 2017). VDR regulates the actions of 1,25(OH)2D and their binding recruits coactivators (Eelen et al. 2005, Kim et al. 2005, Du et al. 2017) to initiate a signaling response that regulates an estimated upwards of 2000 genes involved in calcium homeostasis, immune responses, cellular growth, differentiation and apoptosis (Hossein-nezhad et al. 2013, Hossein-nezhad & Holick 2013, Wolden-Kirk et al. 2012, Prietl et al. 2013, Hewison 2012, Christakos et al. 2016, Bandera Merchan et al. 2017).

Literature References
PubMed ID Title Journal Year
15728261 Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction

Eelen, G, Verlinden, L, Rochel, N, Claessens, F, De Clercq, P, Vandewalle, M, Tocchini-Valentini, G, Moras, D, Bouillon, R, Verstuyf, A

Mol. Pharmacol. 2005
21849106 Vitamin D and immune function: an overview

Hewison, M

Proc Nutr Soc 2012
23857223 Vitamin D and immune function

Prietl, B, Treiber, G, Pieber, TR, Amrein, K

Nutrients 2013
28206978 Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

Du, C, Yang, S, Zhao, X, Dong, H

Oncotarget 2017
22877430 Extraskeletal effects of vitamin D

Wolden-Kirk, H, Gysemans, C, Verstuyf, A, Mathieu, C

Endocrinol. Metab. Clin. North Am. 2012
27913313 The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences

Bandera Merchan, B, Morcillo, S, Martin-Nuñez, G, Tinahones, FJ, Macías-González, M

J. Steroid Biochem. Mol. Biol. 2017
15647825 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts

Kim, S, Shevde, NK, Pike, JW

J. Bone Miner. Res. 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created