PIAS4 SUMOylates VDR with SUMO2

Stable Identifier
R-HSA-4546387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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E3 SUMO-protein ligase (PIAS4) SUMOylates Vitamin D3 receptor (VDR) with SUMO2 (Jena et al. 2012). SUMOylation inhibits transcriptional activation by VDR in response to vitamin D.

Literature References
PubMed ID Title Journal Year
22564762 PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor

Jena, S, Lee, WP, Doherty, D, Thompson, PD

J. Steroid Biochem. Mol. Biol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created