PIAS4 SUMOylates VDR with SUMO2

Stable Identifier
R-HSA-4546387
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS4 SUMOylates VDR with SUMO2
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E3 SUMO-protein ligase (PIAS4) SUMOylates Vitamin D3 receptor (VDR) with SUMO2 (Jena et al. 2012). SUMOylation inhibits transcriptional activation by VDR in response to vitamin D.

Literature References
PubMed ID Title Journal Year
22564762 PIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor

Lee, WP, Thompson, PD, Doherty, D, Jena, S

J. Steroid Biochem. Mol. Biol. 2012
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates VDR with SUMO2 (Bos taurus)
PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)
PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)
PIAS4 SUMOylates VDR with SUMO2 (Gallus gallus)
PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)
PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)
PIAS4 SUMOylates VDR with SUMO2 (Xenopus tropicalis)
Authored
May, B  (2013-08-19)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-09-06)
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